CORE--TISSUE RESEARCH AND PATHOLGOGY SERVICES

核心——组织研究和病理学服务

• 批准号: 6989547
• 负责人: RAJIV DHIR
• 金额: $ 8.35万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989547
• 关键词: biomedical facility; clinical research; histology; histopathology; human data; neoplasm /cancer; neoplastic process; tissue /cell preparation

The Tissue and Research Pathology Services (TARPS) is a newly proposed shared facility that serves as the central support for UPCI research programs needing tissue materials from patients at the University of Pittsburgh Medical Center (UPMC). The main objectives of TARPS are (1) to provide a mechanism to simplify and streamline the process of research tissue accrual and disbursement and (2) to provide efficient research pathology support services. The tissue accrual and disbursement function of TARPS has been in existence since 1991 as a small service facility, with a focus on genitourinary cancers. The resource has substantially expanded in the last 5 years and now procures and disburses tissue materials from patients with a diverse array of cancers, and provides support to major research projects such as the hmg Specialized Program Of Research Excellence (SPORE), Early Disease Research Network (EDRN)-related research efforts, and several other cancer research programs. Services provided by TARPS include (1) tissue and biological specimen procurement services, (2) research histology services, (3) annotated clinical data, and (4) the Tissue Micro-Array (TMA) facilities. Future efforts include development of procedures to molecularly profile tumors on a real time basis. TARPS plans to extend the development of its infrastructure already in place for cancers such as prostate and head and neck cmacers, to other areas such as gastrointestinal and pancreatic cancers, hematologic malignancies, and melanoma.

组织和研究病理学服务（TARPS）是一个新提出的共享设施，作为UPCI研究计划的中央支持，需要匹兹堡大学医学中心（UPMC）患者的组织材料。TARPS的主要目标是（1）提供一种机制，简化和精简研究组织的积累和支付过程，（2）提供有效的研究病理学支持服务。组织 自1991年以来，该计划一直作为一个小型服务设施，具有累积和支付职能，重点是泌尿生殖系统癌症。该资源在过去5年中大幅扩展，现在从各种癌症患者中采购和支付组织材料，并为重大研究项目提供支持，如hmg专业研究卓越计划（SPORE），早期疾病研究网络（EDRN）相关的 研究工作，以及其他几个癌症研究项目。 TARPS提供的服务包括（1）组织和生物标本采购服务，（2）研究组织学服务，（3）注释临床数据，以及（4）组织微阵列（TMA）设施。未来的努力包括开发程序，以真实的时间为基础的分子概况肿瘤。TARPS计划将其已经用于前列腺癌和头颈癌等癌症的基础设施的发展扩展到其他领域，如胃肠道和胰腺癌、血液恶性肿瘤和黑色素瘤。