Tissue Resource and Morphology Core (TRMC)

组织资源和形态核心 (TRMC)

• 批准号: 10002342
• 负责人: RAJIV DHIR
• 金额: $ 10.98万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-22 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002342
• 关键词: Animal Model; Biocompatible Materials; Biological; Bladder; Blood; Core Facility; Data; Data Collection; Development; Equipment and supply inventories; Genitourinary system; Health Sciences; Histology; Immunohistochemistry; Institutional Review Boards; Morphology; Pathologist; Pathology; Patients; Prostate; Prostatic Diseases; Research; Sampling; Services; Specimen; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Training; Universities; Urine; base; clinically relevant; human tissue; programs; success; tissue culture; tissue resource

Abstract: Results from tissue culture and animal models provide important information, but must be validated in human tissue to be considered clinically relevant. Thus, the success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) will supply such material. The TRMC will be based on the Health Sciences Tissue Bank, a core facility that has been accruing prostate tissue from BPH patients for over 15 years. The Director of the Health Sciences Tissue Bank, Dr. Rajiv Dhir, a board certified pathologist with training in genitourinary pathology, will serve as the TRMC Director. Dr. Dhir will assure the proper use and analysis of BPH specimens in the proposed projects. The TRMC will provide an array of services: (1) Procurement of normal and diseased prostates and bladders; (2) Banking of specimens; (3) Data collection to annotate samples, specimen data entry, and inventory management; (4) Morphology support for appropriate case selection for the proposed studies; (5) Histology support and immunohistochemistry. Tissue microarray development will be done for high throughput assessment, if needed. (6) Support and assistance for Institutional Review Board issues.

文摘: