Tissue Resource and Morphology Core (TRMC)

摘要： 组织培养和动物模型的结果提供了重要的信息，但必须在人类身上进行验证 被认为与临床相关的组织。因此，奥布莱恩中心的成功将取决于 可获得高质量的、适当选择的人体组织标本。组织资源与 形态核心(TRMC)将提供这样的材料。TRMC将以健康科学组织为基础 Bank是一家核心机构，15年来一直在收集BPH患者的前列腺组织。署长 健康科学组织银行的Rajiv Dhir博士，他是一名经过生殖泌尿外科培训的委员会认证病理学家 病理，将担任TRMC主任。Dhir博士将确保BPH的正确使用和分析 拟议项目中的标本。TRMC将提供一系列服务：(1)正常采购 和患病的前列腺和膀胱；(2)标本的储存；(3)数据收集以对样本进行注释， 标本数据输入和库存管理；(4)为适当的病例选择提供形态支持 建议的研究；(5)组织学支持和免疫组织化学。组织微阵列开发将是 用于高吞吐量评估(如果需要)。(6)对院校覆核委员会的支持和协助 问题。

Abstract: Results from tissue culture and animal models provide important information, but must be validated in human tissue to be considered clinically relevant. Thus, the success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) will supply such material. The TRMC will be based on the Health Sciences Tissue Bank, a core facility that has been accruing prostate tissue from BPH patients for over 15 years. The Director of the Health Sciences Tissue Bank, Dr. Rajiv Dhir, a board certified pathologist with training in genitourinary pathology, will serve as the TRMC Director. Dr. Dhir will assure the proper use and analysis of BPH specimens in the proposed projects. The TRMC will provide an array of services: (1) Procurement of normal and diseased prostates and bladders; (2) Banking of specimens; (3) Data collection to annotate samples, specimen data entry, and inventory management; (4) Morphology support for appropriate case selection for the proposed studies; (5) Histology support and immunohistochemistry. Tissue microarray development will be done for high throughput assessment, if needed. (6) Support and assistance for Institutional Review Board issues.