Tissue and Research Pathology Services

组织和研究病理学服务

• 批准号: 10674830
• 负责人: RAJIV DHIR
• 金额: $ 12.57万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-10 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674830
• 关键词: Algorithmic Analysis; American; Antibodies; Apoptosis; Bioinformatics; Biological; Biological Specimen Banks; Bromodeoxyuridine; Budgets; Cancer Center; Cancer Center Support Grant; Cell Proliferation; Certification; Clinical; Clinical Data; Clinical Laboratory Information Systems; Clinical Research; Collection; Community Hospitals; Computerized Medical Record; Cytoplasm; Data; Databases; Development; Diagnostic; Equipment; Ethics; Evaluation; Frozen Sections; Funding; Glass; Goals; Head and neck structure; Health Sciences; Histology; Hospitals; Hour; Human; Image; Image Analysis; Image Enhancement; Immunohistochemistry; Immunologic Monitoring; Individual; Information Retrieval; Institution; Institutional Review Boards; Investigation; Laboratories; Lung; Malignant Neoplasms; Malignant neoplasm of ovary; Medical; Modeling; Monitor; Nuclear; Paraffin Tissue; Pathologist; Pathology; Patients; Pattern; Pediatric Hospitals; Play; Presbyterian Church; Price; Process; Proteomics; Protocols documentation; Registries; Research; Research Personnel; Resource Sharing; Resources; Retrieval; Role; Sampling; Science; Services; Site; Skin Cancer; Slide; Specimen; Stains; Supervision; System; Systems Analysis; TdT-Mediated dUTP Nick End Labeling Assay; Techniques; Text; The Cancer Genome Atlas; Tissue Banks; Tissue Microarray; Tissue Preservation; Tissue Sample; Tissues; Translational Research; Triage; Trichrome stain method; Universities; Woman; Work; automated image analysis; biobank; college; cost; data centers; data management; design; experience; imaging facilities; innovation; interest; liquid crystal polymer; manufacture; melanoma; member; morphometry; novel; pre-clinical research; programs; quantitative imaging; research facility; research study; sample collection; service utilization; tumor; whole slide imaging

Abstract: Tissue and Research Pathology Services (TARPS) One of the essential components of any translational research investigation is the availability of high quality, appropriately selected human biospecimen samples. The Hillman Cancer Center (HCC) recognized the value of a good, systematic, scientifically, and ethically correct biospecimen repository more than 18 years ago and implemented a system-wide initiative for tissue and biological specimen accrual with the establishment of the Tissue and Research Pathology Service (TARPS) Shared Resource under the umbrella of the University of Pittsburgh (Pitt) resource also known as the Pitt Biospecimen Core (formerly the Health Sciences Tissue Bank). TARPS has been housed and extensively supported by HCC and the Department of Pathology. This has led to the development of a well-organized biospecimen resource, providing high-quality, well-banked specimens with extensive database support providing the clinical annotation so essential to good research. TARPS is a CAP-certified biorepository and serves as the central hub, acquiring and triaging biospecimen materials and de-identified patient information. It is currently housed within the Department of Pathology diagnostic evaluation facilities, thus providing immediate access to specimens and patient information of interest. The resource has Pathologist administrative oversight and medical supervision at the three flagship hospitals (Presbyterian, Shadyside, Magee), and the largest community hospital (Passavant), with plans in progress to add Children’s Hospital of Pittsburgh later in 2019. At HCC, TARPS has played an instrumental role in supporting multi-investigator and multi-institutional efforts including: The Cancer Genome Atlas Project (TCGA); the caHUB project as a funded site for the Biospecimen Pre-analytical Variables (BPV) task order; the NCI’s Clinical Proteomic Tumor Analysis Consortium (CPTAC), SPOREs in lung, head and neck, melanoma and skin, and ovarian cancers and many other collaborative team science projects. In FY2019, 65 out of 121 users were HCC members representing 6 CCSG research programs (CB, CEP, CII, CT, CV and GS). Usage was stable from 79% to 91% between 2015 and 2019.

翻译后摘要：组织和研究病理学服务（TARPS） 任何翻译研究调查的重要组成部分之一是高质量的可用性， 适当选择人体生物标本样本。希尔曼癌症中心（HCC）认识到 一个良好的，系统的，科学的，道德上正确的生物标本储存库超过18年前， 实施了一项全系统组织和生物标本累积举措， 组织和研究病理学服务（TARPS）共享资源的伞下的大学 匹兹堡（皮特）资源也被称为皮特生物标本核心（前身为健康科学组织） 银行）。TARPS已被安置和广泛支持HCC和病理学系。这 导致了组织良好的生物标本资源的发展，提供了高质量， 具有广泛数据库支持的标本，为良好的研究提供了至关重要的临床注释。 TARPS是一个CAP认证的生物储存库，并作为中心枢纽，获取和分类生物标本 材料和去识别的患者信息。它目前设在病理学系 诊断评估设施，从而提供即时访问的标本和病人的信息， 兴趣该资源有病理学家行政监督和医疗监督在三个旗舰 医院（长老会，沙迪赛德，马吉）和最大的社区医院（帕萨万特），计划在 计划于2019年晚些时候增加匹兹堡儿童医院。 在HCC，TARPS在支持多研究者和多机构的努力方面发挥了重要作用 包括：癌症基因组图谱项目（TCGA）;作为生物标本资助网站的caHUB项目 预分析变量（BPV）任务顺序; NCI的临床蛋白质组学肿瘤分析联盟（CPTAC）， SPORE在肺癌、头颈癌、黑色素瘤、皮肤癌、卵巢癌等多个领域的合作团队 科学项目。于2019财政年度，121名用户中有65名为HCC会员，代表6项CCSG研究 程序（CB，CEP，CII，CT，CV和GS）。在2015年至2019年期间，使用率稳定在79%至91%之间。