Tissue and Research Pathology Services

组织和研究病理学服务

• 批准号: 10024346
• 负责人: RAJIV DHIR
• 金额: $ 12.37万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-10 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10024346
• 关键词: Algorithmic Analysis; American; Antibodies; Apoptosis; Bioinformatics; Biological; Biological Specimen Banks; Bromodeoxyuridine; Budgets; Cancer Center; Cancer Center Support Grant; Cell Proliferation; Clinical; Clinical Data; Clinical Laboratory Information Systems; Clinical Research; Collection; Community Hospitals; Computerized Medical Record; Cutaneous Melanoma; Data; Databases; Development; Diagnostic; Equipment; Ethics; Evaluation; Frozen Sections; Funding; Glass; Goals; Head and neck structure; Health Sciences; Histology; Hospitals; Hour; Human; Image; Image Analysis; Image Enhancement; Immunohistochemistry; Immunologic Monitoring; Individual; Information Retrieval; Institutional Review Boards; Investigation; Laboratories; Lung; Malignant Neoplasms; Malignant neoplasm of ovary; Medical; Modeling; Monitor; Nuclear; Paraffin Tissue; Pathologist; Pathology; Patients; Pattern; Pediatric Hospitals; Plant Roots; Play; Presbyterian Church; Price; Process; Proteomics; Protocols documentation; Registries; Research; Research Personnel; Resource Sharing; Resources; Retrieval; Role; Sampling; Science; Services; Site; Skin Cancer; Slide; Specimen; Stains; Supervision; System; Systems Analysis; TdT-Mediated dUTP Nick End Labeling Assay; Techniques; Text; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Preservation; Tissue Sample; Tissues; Translational Research; Triage; Trichrome stain method; Universities; Woman; Work; automated image analysis; biobank; college; cost; data centers; data management; design; experience; imaging facilities; innovation; interest; liquid crystal polymer; member; morphometry; novel; pre-clinical research; programs; quantitative imaging; research facility; research study; sample collection; service utilization; tumor; whole slide imaging

Abstract: Tissue and Research Pathology Services (TARPS) One of the essential components of any translational research investigation is the availability of high quality, appropriately selected human biospecimen samples. The Hillman Cancer Center (HCC) recognized the value of a good, systematic, scientifically, and ethically correct biospecimen repository more than 18 years ago and implemented a system-wide initiative for tissue and biological specimen accrual with the establishment of the Tissue and Research Pathology Service (TARPS) Shared Resource under the umbrella of the University of Pittsburgh (Pitt) resource also known as the Pitt Biospecimen Core (formerly the Health Sciences Tissue Bank). TARPS has been housed and extensively supported by HCC and the Department of Pathology. This has led to the development of a well-organized biospecimen resource, providing high-quality, well-banked specimens with extensive database support providing the clinical annotation so essential to good research. TARPS is a CAP-certified biorepository and serves as the central hub, acquiring and triaging biospecimen materials and de-identified patient information. It is currently housed within the Department of Pathology diagnostic evaluation facilities, thus providing immediate access to specimens and patient information of interest. The resource has Pathologist administrative oversight and medical supervision at the three flagship hospitals (Presbyterian, Shadyside, Magee), and the largest community hospital (Passavant), with plans in progress to add Children’s Hospital of Pittsburgh later in 2019. At HCC, TARPS has played an instrumental role in supporting multi-investigator and multi-institutional efforts including: The Cancer Genome Atlas Project (TCGA); the caHUB project as a funded site for the Biospecimen Pre-analytical Variables (BPV) task order; the NCI’s Clinical Proteomic Tumor Analysis Consortium (CPTAC), SPOREs in lung, head and neck, melanoma and skin, and ovarian cancers and many other collaborative team science projects. In FY2019, 65 out of 121 users were HCC members representing 6 CCSG research programs (CB, CEP, CII, CT, CV and GS). Usage was stable from 79% to 91% between 2015 and 2019.

摘要：组织和研究病理学服务(TARPS) 任何翻译研究调查的基本组成部分之一是高质量的可用性， 经过适当选择的人类生物样品。希尔曼癌症中心(HCC)认识到了这一价值 一个良好的、系统的、科学的和道德上正确的生物质谱库 实施了全系统组织和生物标本应计倡议，设立了 组织和研究病理学服务(TARPS)在华盛顿大学的保护伞下共享资源 匹兹堡(PITT)资源，也称为PITT BIOSPECIMEN CORE(前身为健康科学组织 银行)。不良资产救助计划得到了肝细胞癌和病理部门的广泛支持和支持。这 已经导致了一个组织良好的生物谱系资源的发展，提供了高质量的，银行充足的 具有广泛数据库支持的标本提供了对良好研究至关重要的临床注释。 TARPS是CAP认证的生物信息库，是获取和分类生物样本的中心枢纽 材料和未确认身份的患者信息。目前它被安置在病理学系 诊断评估设施，从而提供对样本和患者信息的即时访问 利息。该资源在三个旗舰机构设有病理学家、行政监督和医疗监督 医院(长老会医院、沙德赛德医院、玛吉医院)和最大的社区医院(帕萨万特)，计划在 2019年晚些时候增加匹兹堡儿童医院的进展。 在中心，问题资产救助计划在支持多个研究人员和多机构努力方面发挥了重要作用 包括：癌症基因组图谱项目(TCGA)；caHUB项目，作为生物谱系的资助地点 分析前变量(BPV)任务顺序；NCI的临床蛋白质组肿瘤分析联盟(CPTAC)， 肺部、头颈部、黑色素瘤和皮肤的孢子，以及卵巢癌和其他许多合作小组 科学项目。在2019财年，121个用户中有65个是代表6个CCSG研究的肝细胞癌成员 计划(CB、CEP、CII、CT、CV和GS)。2015至2019年间，使用率稳定在79%至91%之间。