Simultaneous Electrophysiology and functional MRI

同步电生理学和功能性 MRI

基本信息

批准号：
6640183
负责人：
Mark Steven Cohen
金额：
$ 22.59万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-06-01 至 2005-05-31
项目状态：
已结题

项目摘要

Functional MRI (fMRI) has become a dominant tool in the physiological studies of human cognition and behavior. The moment- to-moment signaling within the brain, however, is understood to be fundamentally electrical. Despite over a decade of applied fMRI research the precise relationship the vascular signals in fMRI and the electrical activity of the brain is largely unknown. In this CEBRA application, we propose to complete development of our methods of simultaneous EEG and fMRI and to adapt these to the recording of extracellular potentials. We believe that we have come up with robust solutions for recording microVolt EEG signals in the presence of milliVolt MR-generated artifacts and are now prepared to enter a development phase for this technology during which we can complete the construction of apparatus appropriate for human research applications. It has long been clear that the problems of concurrent EEG and fMRI are similar to those in concurrent extracellular recording and fMRIas the sources of artifacts are essentially the same. In fact, the signal to noise ratio for the latter should be somewhat better. There are however, significant hurdles to overcome in studying and controlling the safety of such recordings, which are the focus of much of this grant proposal. We believe that this is an exceptionally significant project, in that these tools will enable us to perform crucial validation experiments that will be important in firming the very foundations on which the interpretation of functional MRI is based. Within the limited confines of the budget for the CEBRA program, the project will stop short of actual human experimentation with depth electrodes - the human work will be limited to scalp EEG to stay within the limited scope of the stage I mechanism. On its successful completion, the project will be followed immediately by an application for Stage II support to begin animal experimentation and shortly thereafter to initiate human studies.

功能性MRI（fMRI）已成为人类认知和行为生理研究中的主要工具。然而，大脑内部的瞬间信号传导在根本上是电气的。尽管有十多年的fMRI研究，精确的关系还是fMRI中的血管信号和大脑的电活动在很大程度上是未知的。在此CEBRA应用中，我们建议完成同时脑电图和fMRI方法的发展，并将其适应细胞外电位的记录。我们认为，我们已经提出了可靠的解决方案，用于在毫伏特MR生成的工件的情况下记录微伏EEG信号，现在准备进入该技术的开发阶段，在此期间，我们可以完成适合人类研究应用程序的设备的构建。长期以来，很明显，并发性脑电图和fMRI的问题与同时存在的细胞外记录和FMRIAS中的问题相似。伪像的来源基本相同。实际上，后者的噪声比应该更好。但是，在研究和控制此类录音的安全方面有重大障碍需要克服，这是本赠款提案的大部分内容的重点。我们认为，这是一个非常重要的项目，因为这些工具将使我们能够执行关键的验证实验，这对于突破功能MRI解释的基础很重要。在CEBRA计划预算的有限范围内，该项目将停止使用深度电极进行实际的人类实验 - 人类的工作将仅限于头皮EEG，以保持在阶段I机制的有限范围内。成功完成后，该项目将立即提出II期支持的申请，以开始动物实验，此后不久就开始了人类研究。