Microphysiological models for the assessment of pulmonary concentration of inhaled aerosols

用于评估吸入气溶胶肺部浓度的微生理学模型

• 批准号: 2446873
• 金额: --
• 依托单位: University of Hertfordshire
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2446873
• 关键词: Microphysiological; models; assessment; pulmonary; concentration

Inhaled aerosols are the treatment of choice for pulmonary diseases. Despite their common therapeutic use, many uncertainties regarding their pulmonary pharmacokinetic profile exist, linked to the difficulty of measuring properties in place. Knowing the region of deposition and local rate of permeation would allow elucidation of absorption processes for inhaled compounds. Given that, a new model is required. To cut costs and animal burden, in vitro assay is a straightforward solution. An emerging technology known as organ-on-chip has opened a new frontier of biorelevant investigative tools, allowing a 3D translation of organs on a microscale. The core of this proposal is to present a review of the current state-of-the-art in terms of knowledge gaps in pulmonary pharmacokinetics and provide elements for the construction of an in vitro model, to address such questions.

吸入气雾剂是治疗肺部疾病的首选。尽管它们具有常见的治疗用途，但其肺部药代动力学特征存在许多不确定性，这与难以测量适当的性质有关。了解沉积区域和局部渗透速率将有助于阐明吸入化合物的吸收过程。因此，需要一种新的模式。为了降低成本和动物负担，体外测定是一种简单的解决方案。一种被称为器官芯片的新兴技术开辟了生物相关研究工具的新前沿，允许在微观尺度上进行器官的3D平移。该提案的核心是对肺药代动力学知识差距方面的当前最新技术水平进行综述，并为构建体外模型提供要素，以解决此类问题。