FLYBASE: A DROSOPHILA GENOMIC & GENETIC DATABASE

简介（申请人提供）：FlyBase是一个主要遗传模式生物果蝇、黑腹果蝇及果蝇科相关生物的核心遗传和基因组信息数据库。在了解基因及其编码产物驱动复杂生物过程（如胚胎身体结构的形成或神经系统的连接）的复杂相互作用方面，黑腹龙一直是，并将继续是先驱生物。有证据表明，这种复杂的生物事件有一个古老的起源，早于昆虫和脊椎动物谱系的分裂，这意味着在黑腹龙身上进行的复杂生物过程的基础研究直接影响了我们对人类生物学和疾病的可比过程的理解。事实上，大多数与疾病相关的人类基因在果蝇中都有密切相关的基因。充满活力的果蝇研究界继续进行着大量的基础研究，对于整个科学界的进步来说，有一个中心资源来捕捉、组织和呈现这些信息，不仅对果蝇专家，而且对更广泛的研究界来说，都是必不可少的。FlyBase服务于这一角色，并捕获了D. melanogaster基因组和相关基因组的DNA序列的主要信息，以及其编码的转录本和蛋白质，经典和转基因突变，表型，菌株收集等。这些数据可以作为公共资源访问，不受限制，通过互联网或批量下载，并被组织起来，以便对果蝇文献和基因组计划进行复杂的查询。基于从科学文献和大规模数据生产者获得的信息，FlyBase项目未来5年的具体目标将包括捕获、组织和展示：(1)附在果蝇基因组序列上的一套全面的注释，包括编码产物以及DNA上介导基因表达调控和染色体结构的位点；(2)基因及其突变等位基因的基本遗传学信息；(3)第1项和第2项中描述的基本遗传/基因组对象之间的关系，例如它们在染色体和序列图上的位置；它们相互作用产生细胞、组织和整个生物体的调节回路，它们在空间和时间上的解剖分布，以及它们在种群和表型类别中的变化。

DESCRIPTION (provided by applicant): FlyBase is a database of the core genetic and genomic information on the major genetic model organism, the fruit fly, Drosophila melanogaster, and related organisms of the family Drosophilidae. D. melanogaster has been, and continues to be the pioneering organism in understanding the intricate interplay of genes and their encoded products to drive complex biological processes such as the formation of the body plan of an embryo or the wiring of the nervous system. The evidence that such complex biological events has an ancient origin, predating the split of the insect and vertebrate lineages, means that the fundamental studies on complex biological processes that are carried out in D. melanogaster directly impact on our understanding of comparable processes in human biology and disease. Indeed, the majority of human genes associated with disease have closely related genes in Drosophila. The very vibrant Drosophila research community continues to carry out a great deal of fundamental research, and it is imperative to the progress of the scientific community as a whole that there is a central resource that captures, organizes and presents this information in a way that is readily accessible not only to experts in the fly, but to the broader research community. FlyBase serves that role, and captures the primary information on the DNA sequence of the D. melanogaster genome and related genomes, as well as its encoded transcripts and proteins, classical and transgenic mutations, phenotypes, strain collections, etc. These data can be accessed as a public resource, without restriction, by means of the Internet or as bulk downloads, and are organized so that complex queries of the Drosophila literature and genome projects can be carried out. Specific goals for the next 5 years of the FlyBase project, based on information garnered from the scientific literature and from large-scale data producers, will include capture, organization and presentation of: (1) a comprehensive set of annotations attached to the Drosophila genomic sequence, both in terms of the encoded products as well as the sites on the DNA that mediate regulation of gene expression and the architecture of chromosomes, (2) information on the basic genetics of genes and their mutant alleles, and (3) the relationship of the fundamental genetic/genomic objects described in items 1 and 2 to each other, e.g., their location on chromosomal and sequence maps, their interactions to produce the regulatory circuitry of cells, tissues and whole organisms, their anatomical distribution, both spatially and temporally, and their variation in populations and phenotypic classes.