Endocrinology-Reproductive Physiology Training Grant

描述（由申请人提供）：从研究和健康的角度来看，需要更好地了解生殖机制和相关的健康问题是控制人口的一个主要因素，并间接消除贫困。相反，生殖研究也可以为不孕不育提供解决方案。这些领域，以及顺利完成妊娠至足月无疾病，不仅与孕产妇和胎儿的健康直接相关，而且正常妊娠也是进入成年期长期健康的重要关键，内分泌学-生殖生理学（ERP）计划大学的威斯康星州，麦迪逊，是一个长期的跨部门计划，重点关注内分泌学和生殖生理学。我们的目标是在生殖生理学和健康的最前沿跨学科研究中提供博士前和博士后水平的培训，并提供一个核心，使来自校园的教师和学生都可以见面并发挥协同作用。在各种哺乳动物物种/细胞模型中的研究涵盖了排卵、精子活力和受精、着床和胎盘形成的神经内分泌和内分泌控制，以及子宫胎盘血流的控制/维持和足月及以后的正常发育。此外，还有几个教师直接调查发育方面以及与怀孕有关的疾病，包括先兆子痫，青春期的时间，更年期，宫内发育迟缓，多囊卵巢综合征的产前规划和生育的社会/压力抑制。最后，我们的许多教师在细胞信号传导的更一般的领域领先，这与生殖生理学的各个方面高度相关，特别是人类生殖。ERP项目目前有31名研究生，其中26名是博士。候选人（18名国内人员，8名国际人员）。到目前为止，自1963年以来，该计划已毕业129硕士。156位博士候选人，其中许多人已经在生殖生理学领域取得了杰出的成就。该提案的目的是寻求对六个博士前职位的五年支持。培训提案包括来自企业资源规划系统的18名培训员，该系统也提供集中管理。这笔资金将支持该计划中近一半符合条件的学生。学员将获得博士学位。候选人，并将支持长达两年后，他们完成了至少一年的培训。博士毕业的平均时间候选人目前是5-6年。招聘少数民族的ERP程序是在各级寻求，并通过ERP程序/教师与威斯康星州系统的大学一起协调行动促进。暑期奖学金、旅行基金和/或两年期的Dispensing和少数民族奖学金也支持这些招聘工作。

DESCRIPTION (provided by applicant): From a research and health perspective, the need for a greater understanding of reproductive mechanisms and related health issues is a major factor in population control and, indirectly, the eradication of poverty. Conversely studies in reproduction can also provide solutions to infertility. These areas, as well as the successful completion of gestation to term free of disease are not only of immediate relevance to maternal and fetal health but normal gestation is also an important key to long term health far into adulthood, The Endocrinology-Reproductive Physiology (ERP) Program at the University of Wisconsin, Madison, is a longstanding interdepartmental program focused on the endocrinology and physiology of reproduction. Our aim is to provide training at the predoctoral and postdoctoral level in interdisciplinary research at the forefront of reproductive physiology and health, as well as provide a nucleus by which both faculty and students from across campus can meet and synergize. Research in a variety of mammalian species/cell models cover neuroendocrine and endocrine control of ovulation, sperm motility and fertilization, implantation and placentation as well as control/maintenance of uteroplacental blood flow and to normal development to term and beyond. In addition, there are several faculty directly investigating aspects of development as well as pregnancy related diseases, including preeclampsia, timing of puberty, menopause, intrauterine growth retardation, prenatal programming of polycystic ovarian syndrome and social/stress inhibition of fertility. Finally, many of our faculty lead the field in more general areas of cell signaling, which is highly relevant to all aspects of reproductive physiology, ing general, and human reproduction in particular. The ERP program currently has 31graduate students of which 26 are Ph.D. candidates (18 domestic, eight international). To date, since 1963, the program has graduated 129 M.S. and 156 Ph.D. candidates, many of who have gone on to prominent careers in reproductive physiology. The aim of this proposal is to seek support for six predoctoral positions for five years. The training proposal includes 18 trainers from the ERP, which also provides centralized administration. This funding will support almost half of the eligible students in the program. Trainees will be Ph.D. candidates and will be supported for up to two years each after they have completed at least one year of training. The average time to graduation for Ph.D. candidates is currently 5-6 years. The recruitment of minorities to the ERP program is sought at all levels and is facilitated by the coordinated actions of the ERP program/faculty together with the University of Wisconsin system. Summer Studentships, travel funds and/or two year Disadvantaged and Minority Fellowships also support these recruitment efforts.