Endocrinology-Reproductive Physiology Training Grant

描述（由申请人提供）：内分泌学和生殖生理学（ERP）研究生培训计划是一个跨学科的内分泌计划，主要关注生殖生物学和生理学，与孕产妇和儿童健康以及宫内编程和成人发病疾病的起源直接相关。这是通过从干细胞和分子生物学到比较生理学的多学科方法来实现的。2004年，我们开始了目前的T32资助，并在进一步发展我们的培训计划方面取得了实质性进展，特别是在专业发展和少数民族招聘方面。我们的第一批学生毕业的成果在出版物和安置方面都很出色，下面详细介绍。同样，出版物一级的生产率也很高。我们还在建立NIH正式声明的最佳培训方面取得了实质性进展，即，最好的翻译研究培训经验发生在强调多学科和跨学科团队的翻译部分的环境中，其成员都是医学博士和博士。为此，我们最近加入了MD研究员进行研究生学位学习，在ERP内创建的新开发的学位奖学金轨道。虽然医学博士候选人不是T32博士预科申请支持的候选人，但我们希望评审人员知道它的存在，并且我们现在正在为这些医学博士博士后学员申请额外的支持。我们相信所有的MD和PhD学员都能从手头研究项目的集体“翻译对话”中受益，这种对话促进了未来翻译工作的实践和理论模式的发展。最终的结果是一个更强大，更充满活力的培训环境，招聘更多的教师，让所有人都能享受。这种混合的培训环境是非常需要的，如果我们要保持一个跨学科的翻译研究团队成员的未来池，否则减少对研究人员的支持，并增加对临床医生的要求在诊所的时间。最后，我们继续修改和扩大我们的举措，以招募学生的多样性，并为此目的，我们现在一直在密切合作，与我们的新助理主任多样性倡议，以建立联系和更有效的战略，既招募和支持这些学员。这是一个杰出的成功，因此该计划在未来五年内继续成为全国排名的生殖生理学培训中心。 公共卫生相关性：怀孕期间的问题可能会导致婴儿无法完全发育或早产。现在已知妊娠期和儿童期在子宫内发展的疾病本身会影响成年发病疾病的发展，包括美国人口的“三大疾病”（肥胖症、糖尿病和心血管疾病）。我们的目标是培养妇产科和儿科临床专业的科学家，为当代和后代解决人类健康和发展的这一重要方面。

DESCRIPTION (provided by applicant): The Endocrinology and Reproductive Physiology (ERP) Graduate Training Program is an interdisciplinary endocrine program with a major focus on reproductive biology and physiology, with direct relevance to maternal and child health as well as intrauterine programming and the origins of adult onset disease. This is achieved using multidisciplinary approaches from stem cells and molecular biology to comparative physiology. In 2004 we began our current T32 funding and have since made substantial progress in the further development of our training program, particularly with regard to both professional development and minority recruitment. The outcomes of our first students to graduate have been outstanding both in publications and placement and are detailed fully below. Likewise productivity at the level of publications has been outstanding. We have also made substantial progress in building that which NIH has formally stated is optimal for training, i.e., that the best translational research training experience occurs in an environment that emphasizes the translational component in a multidisciplinary and interdisciplinary team, the members of which are both MDs and PhDs. To that end we have recently been joined by MD fellows undergoing graduate degree study in a newly developed Degree Fellowship Track created within ERP. While MD candidates are not candidates for support under this T32 Predoctoral application, we wish the reviewers to be aware of its existence and that we are now in the process of applying for additional support for these MD postdoctoral trainees in a separate T32 application. We believe all MD and PhD trainees benefit from a collective 'translational dialogue' of the research projects in hand and such a dialogue promotes the development of both practical and theoretical models for translational work in the future. The end result is a stronger, more vibrant training environment with the recruitment of additional faculty, for all to enjoy. This blended training environment is very much needed if we are to maintain a future pool of interdisciplinary translational research team members at a time of otherwise reduced support for research faculty and increasing demands on clinicians to be in the clinics. Finally we have continued to revise and expand our initiatives to recruit students of diversity and to that end we now have been working in close partnership with our new Assistant Director for Diversity Initiatives to create links and more effective strategies to both recruit and support these trainees. This has been an outstanding success and the program is therefore well placed for continuing as a nationally ranked training center for Reproductive Physiology over the next five years. PUBLIC HEALTH RELEVANCE: Problems during pregnancy may cause a baby to fail to fully develop or be born prematurely. Diseases of pregnancy and childhood developed in utero itself are now known to impact on developing adult onset diseases, including the "Big Three" for the US population (Obesity, Diabetes and Cardiovascular Disease). Our goal is to train scientists in the clinical specialties of Ob/Gyn and Pediatrics to address this important aspect of human health and development for both current and future generations.