Integrated Program in Endocrinology Translational Postdoctoral Training Program

内分泌学综合项目转化博士后培训项目

• 批准号: 10646141
• 负责人: IAN M. BIRD
• 金额: $ 24.53万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10646141
• 关键词: Endocrinology; Training Programs; post-doctoral training; programs

Abstract. The rate of progress in understanding the basis for reproductive health and disease is breathtaking, accelerated ever further by constant advances in cellular and molecular techniques. Nonetheless, research in traditional academic departments and research in clinical departments often does not overlap. As such, the PhD trained in a purely academic environment will remain unexposed to the clinical mindset and practices and so fail to pursue translational goals, while the clinician Fellow is well aware of the clinical problem and by definition focused on the human itself, but may be less aware of recent conceptual and methodologic advances available to investigate clinically derived research questions. As PA-18-403 RFA states, “past studies have shown that health professional trainees who train in programs with postdoctoral researchers who have intensive research backgrounds are more likely to apply for and receive subsequent research grant support”. To that end, the goal of this proposal is simple - to provide for the PhD and MD Fellow a combined and integrated immersion experience in a cutting edge cross campus research program that is in itself embedded in and focused upon a more clinical environment where health and disease is the primary consideration, and to then promote the use of nonhuman primate and human derived models in MD or PhD Fellowship projects lead by MD/DVM/PhD Faculty of combined clinical and traditional training backgrounds. The campus home for this program will be the integrated Program in Endocrinology (iPEnd), which was founded in 2016 to foster and promote collaboration focused on fetal development and the compromised adult outcomes of adverse pregnancy. We propose here that iPEnd also offers a vibrant interdisciplinary and multidisciplinary environment comprised of MD, PhD and DVM trained faculty with which both MD and PhD Postdoctoral Fellows could train together to enter the world of translational research. Such a blended training environment is very much needed if we are to maintain a future pool of interdisciplinary translational research team members intellectually and professionally ready to pursue the goals of NICHD to improve reproductive health and outcomes. Another consideration by NIH is that trainees do not go on to future independent success by simple exposure to ‘good science’ alone. Indeed, both Trainees and Trainers need support and professional education to ensure the best outcomes. To that end, our proposed training includes a deep immersion in higher level research training typical of many T32 programs at this time, but we aim to go far beyond to include the evidence based 8 core competencies for Postdoctoral trainees combined with added Mentee and Mentor training and the complimentary Professional Development Resources in order to achieve the rich blended training environment so strongly recommended by NIH. We believe iPEnd is ready to promote the concepts of the interdisciplinary and multidisciplinary ‘Translational Workforce’ through the proposed Training Program, operating within first class campus environment geared for basic but increasingly supportive of translational research. On that basis, we submit this application.

抽象的。在了解生殖健康和疾病的基础方面的进展速度是惊人的， 细胞和分子技术的不断进步进一步加速了这一进程。尽管如此， 传统的学术部门和临床部门的研究往往不重叠。因此，PhD 在纯粹的学术环境中接受培训的人将仍然没有接触到临床思维和实践， 追求翻译目标，而临床研究员是很好地了解临床问题，并根据定义 专注于人类本身，但可能不太了解最近的概念和方法学进展 调查临床衍生的研究问题。正如PA-18-403 RFA所述，“过去的研究表明， 在博士后研究人员的项目中接受培训的卫生专业受训人员， 有研究背景的人更有可能申请并获得随后的研究资助”。为此，目标 这个建议很简单-为博士和MD研究员提供一个综合和综合的沉浸 在一个尖端的跨校园研究计划，这本身就是嵌入式的经验，并集中在一个 更多的临床环境，其中健康和疾病是首要考虑因素，然后推广使用 非人灵长类动物和人类衍生模型在MD或PhD奖学金项目由MD/DVM/PhD领导 结合临床和传统培训背景的学院。该计划的校园之家将是 内分泌学综合计划（iEnd），成立于2016年，旨在促进和促进合作 重点关注胎儿发育和不良妊娠对成人结局的影响。我们在此提议 iEnd还提供了一个充满活力的跨学科和多学科的环境，包括MD，PhD和 DVM培训的教师与MD和博士博士后研究员可以一起培训，进入世界 翻译研究如果我们要保持未来， 跨学科的翻译研究团队成员的智力和专业准备追求池 国家儿童健康与发展委员会改善生殖健康和成果的目标。NIH的另一个考虑是， 不要仅仅通过简单地接触“好的科学”来获得未来的独立成功。事实上，两名学员 培训师需要支持和专业教育，以确保取得最佳成果。为此，我们建议 培训包括深度沉浸在更高层次的研究培训典型的许多T32计划在这个时候， 但我们的目标远远超出了包括基于证据的8个核心能力的博士后学员 结合额外的学员和导师培训以及免费的专业发展资源 以实现NIH强烈推荐的丰富的混合训练环境。我们相信iPend 准备通过以下方式促进跨学科和多学科的“翻译工作队伍”的概念 拟议的培训计划，在一流的校园环境中运作，面向基本的，但 越来越多地支持翻译研究。在此基础上，我们提出了这一申请。

项目成果

Src kinase partially mediates cytokine-induced endothelial dysfunction.

Src 激酶部分介导细胞因子诱导的内皮功能障碍。

• DOI: 10.1016/j.preghy.2023.10.004
• 发表时间: 2023
• 期刊: Pregnancy hypertension
• 作者: Mauro,AmandaK;Clemente,Luca;Khurshid,Nauman;Shah,DineshM;Zheng,Jing;Boeldt,DerekS
• 通讯作者: Boeldt,DerekS