CORE--IRRADIATION

福克斯蔡斯癌症中心（FCCC）的辐照设施管理着 电离辐射源根据我们的核许可证中规定的程序， 监管委员会（NRC）。管理和维护这些潜在的危险， 将昂贵的设备（每个100，000 - 200，000美元）作为多个用户的共享资源， 管理、质量保证、安全和法规遵从性。该设施包括两个 不同的辐照器，每个都根据其特定用途进行了优化。他们生产铯-137 伽马射线照射溶液、细胞培养物、啮齿动物肿瘤或正常组织中的分子， 放射生物学机制的研究，抑制免疫反应，诱导DMA损伤和/或有丝分裂停滞，以及使细胞和药物制剂灭菌。Shepherd Model 280辐照器位于实验室动物设施中，主要用于免疫生物学研究中使用的动物的全身辐照（参见Hayakawa等人，J. Exp. 197：87-99，2003; Allman等人，167：6834-6840，2001）。全景Shepherd 81- 14 R型辐照器位于Reimann大楼的地下室。在2003年，它被使用了223次，主要用于照射细胞（参见，例如，Katz等人，J. Virol. 76：5422-5434，2002; Mu等人，国际放射学杂志Oncol. 58：336-343，2004）。设施经理、设施主任、辐射安全官员、辐射安全委员会、FCCC管理局和核管制委员会负责监督设施的运行。设施工作人员操作各种辐射剂量计，以准确确定实验装置的剂量，并可供气候变化框架公约调查人员规划辐射实验，协助不经常使用的用户，培训个人成为雅阁核管制委员会和其他安全条例的合格辐照器用户，并监督设备的年度维护和质量保证。根据国土安全部的威胁等级，每隔一段时间对放射源进行清点。在上一个核心赠款周期中，来自两个中心司的10个气候变化框架公约研究方案的24名经同行评审的受资助研究人员使用了该基金。目前，92%的设施是由同行评审资助的研究人员使用的。设施的使用每年增加约10%，预计在下一个核心赠款周期内每年增加5-10%。

The Irradiation Facility at Fox Chase Cancer Center (FCCC) manages the shared use of ionizing radiation sources according to procedures mandated in our license from the Nuclear Regulatory Commission (NRC). Management and maintenance of these potentially dangerous, costly devices ($100,000-$200,000 each) as a shared resource for multiple users facilitates administration, quality assurance, safety and regulatory compliance. The Facility consists of two different irradiators, each sited optimally for its specific use. They produce fields of Cesium-137 gamma-rays to irradiate molecules in solution, cell cultures, rodent tumors or normal tissues for studies of radiobiologic mechanisms, to suppress immune response, to induce DMA damage and/or mitotic arrest, and to sterilize cell and drug preparations. The Shepherd Model 280 irradiator is situated in the Laboratory Animal Facility and used mainly for whole body irradiation of animals used in immunobiology research (see Hayakawa et al., J. Exp. Med. 197:87-99, 2003; Allman et al., J. Immunol. 167:6834-6840, 2001). The panoramic Shepherd Model 81-14R irradiator is situated in the basement of the Reimann Building. It was used 223 times in 2003 primarily for the irradiation of cells (see, for example, Katz et al., J. Virol. 76:5422-5434, 2002; Mu et al., Int. J. Radiat. Oncol. Biol. Phys. 58:336-343, 2004). Oversight of Facility operation is provided by the Facility Manager, Facility Director, Radiation Safety Officer, Radiation Safety Committee, FCCC Administration and the NRC. Facility staff operate various radiation dosimeters to accurately determine the dose to experimental set-ups and is available to FCCC investigators for planning radiation experiments, to assist infrequent users, for training individuals to become qualified irradiator users in accord with NRC and other safety regulations and for overseeing the annual maintenance and quality assurance of equipment. Inventories of the radioactive sources are made at intervals determined by the Homeland Security threat level. Over the last Core grant cycle, the Facility was used by 24 peer-reviewed funded investigators from ten FCCC research Programs in two Center Divisions. Currently, 92% of Facility use is by peer-reviewed funded investigators. Facility use has increased about 10% per year and is projected to increase 5-10% per year during the next Core grant cycle.