FT-ICR MASS Spectrometer

FT-ICR质谱仪

• 批准号: 6803715
• 负责人: RUTH Hogue ANGELETTI
• 金额: $ 166.68万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803715
• 关键词: biological signal transduction; biomedical equipment purchase; mass spectrometry; structural biology

DESCRIPTION (provided by applicant): This proposal requests a 9.4T Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS or FTMS) for applications in structural biology, signal transduction, and biological discovery. There is local expertise in the use of FT-ICR-MS, and a long track record of the PI and this group in effective use and tong term support of shared resources and instrumentation.

描述（由申请人提供）： 该提案要求9.4T傅立叶变换离子回旋共振质谱仪（FT-ICR MS或FTMS）在结构生物学，信号转导和生物发现中的应用。在FT-ICR-MS的使用方面有当地的专业知识，PI和该小组在有效使用和长期支持共享资源和仪器方面有长期的记录。

项目成果

Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization.

• DOI: 10.1021/bi901351q
• 发表时间: 2009-12-15
• 期刊: BIOCHEMISTRY
• 影响因子: 2.9
• 作者: Khrapunovich-Baine, Marina;Menon, Vilas;Verdier-Pinard, Pascal;Smith, Amos B., III;Angeletti, Ruth Hogue;Fiser, Andras;Horwitz, Susan Band;Xiao, Hui
• 通讯作者: Xiao, Hui

Conformation changes in E. coli Rho monitored by hydrogen/deuterium exchange and mass spectrometry: response to ligand binding.

通过氢/氘交换和质谱法监测大肠杆菌 Rho 的构象变化：对配体结合的响应。

• DOI: 10.1016/j.jmb.2010.08.004
• 发表时间: 2010
• 期刊: Journal of molecular biology
• 影响因子: 5.6
• 作者: Stitt,BarbaraL;Xiao,Hui
• 通讯作者: Xiao,Hui

Binding interface of cardiac potassium channel proteins identified by hydrogen deuterium exchange of synthetic peptides.

通过合成肽的氢氘交换鉴定心脏钾通道蛋白的结合界面。

• DOI: 10.1007/s00216-012-5857-2
• 发表时间: 2012
• 期刊: Analytical and bioanalytical chemistry
• 影响因子: 4.3
• 作者: Chen,Jerri;Angeletti,Ruth;McDonald,ThomasV;Xiao,Hui
• 通讯作者: Xiao,Hui