Pilot Proteomics Center on Drug Abuse HIV/AIDS

药物滥用艾滋病毒/艾滋病蛋白质组学试点中心

• 批准号: 8034376
• 负责人: RUTH Hogue ANGELETTI
• 金额: $ 95.59万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8034376
• 关键词: Pilot; Proteomics; Center; Drug; Abuse

DESCRIPTION (provided by applicant): The mission of the Einstein HAND Proteomics Research Center is to evaluate the interactions of drug addiction and its treatment on the development and progression of HIV associated neurocognitive disorders (HAND). The central research themes of the pilot Einstein HAND Proteomics Research Center (EHPRC) will focus on investigating the mechanism by which HIV infection causes HAND, identifying biomarkers for the onset and course of HAND and the potential additive impact of buprenorphine treatment on the development and progression of HAND by utilizing proteomic approaches in humans, animal models and cell culture. The EHPRC will provide the proteomics, bioinformatics, data integration, and statistical support for three synergistic projects. Scientific interactions and project integration will be fostered by a laboratory information management system (LIMS), an EHPRC web site, weekly lab meetings of EHPRC members, and annual presentations at meetings with internal and external advisory committees.

描述(申请人提供)：爱因斯坦手蛋白质组学研究中心的使命是评估药物成瘾及其治疗对艾滋病毒相关神经认知障碍(HAND)的发展和进展的交互作用。爱因斯坦手部蛋白质组学试点研究中心(EHPRC)的中心研究主题将集中在利用人类、动物模型和细胞培养的蛋白质组学方法，研究艾滋病毒感染导致手部疾病的机制，确定手部疾病的发病和病程的生物标志物，以及丁丙诺啡治疗对手部发育和进展的潜在相加影响。EHPRC将为三个协同项目提供蛋白质组学、生物信息学、数据集成和统计支持。科学互动和项目整合将通过实验室信息管理系统(LIMS)、EHPRC网站、EHPRC成员每周实验室会议以及在与内部和外部咨询委员会举行的年度会议上进行介绍来促进。

项目成果

A label-free mass spectrometry method for relative quantitation of β-tubulin isotype expression in human tumor tissue.

• DOI: 10.1002/prca.201200018
• 发表时间: 2012-10
• 期刊: PROTEOMICS CLINICAL APPLICATIONS
• 影响因子: 2
• 作者: Miller, Leah M.;Yang, Chia-Ping Huang;Xiao, Hui;Isaac, Sylvie;Seve, Pascal;Dumontet, Charles;Horwitz, Susan Band;Angeletti, Ruth Hogue
• 通讯作者: Angeletti, Ruth Hogue