Pilot Proteomics Center on Drug Abuse HIV/AIDS

描述（由申请人提供）：爱因斯坦HAND蛋白质组学研究中心的任务是评估药物成瘾及其治疗对HIV相关神经认知障碍（HAND）的发展和进展的相互作用。试点Einstein HAND蛋白质组学研究中心（EHPRC）的中心研究主题将集中于研究HIV感染导致HAND的机制，识别HAND发病和病程的生物标志物，以及丁丙诺啡治疗对HAND发展和进展的潜在附加影响，利用蛋白质组学方法在人类，动物模型和细胞培养中进行研究。EHPRC将为三个协同项目提供蛋白质组学、生物信息学、数据集成和统计支持。通过实验室信息管理系统（LIMS）、EHPRC网站、EHPRC成员的每周实验室会议以及与内部和外部咨询委员会的年度会议报告，将促进科学互动和项目整合。

DESCRIPTION (provided by applicant): The mission of the Einstein HAND Proteomics Research Center is to evaluate the interactions of drug addiction and its treatment on the development and progression of HIV associated neurocognitive disorders (HAND). The central research themes of the pilot Einstein HAND Proteomics Research Center (EHPRC) will focus on investigating the mechanism by which HIV infection causes HAND, identifying biomarkers for the onset and course of HAND and the potential additive impact of buprenorphine treatment on the development and progression of HAND by utilizing proteomic approaches in humans, animal models and cell culture. The EHPRC will provide the proteomics, bioinformatics, data integration, and statistical support for three synergistic projects. Scientific interactions and project integration will be fostered by a laboratory information management system (LIMS), an EHPRC web site, weekly lab meetings of EHPRC members, and annual presentations at meetings with internal and external advisory committees.