SUPPLEMENTAL INTRAVENOUS IRON THERAPY FOR RLS

我们的核心概念是，RLS与铁利用的潜在问题有关。这可能是特定于大脑或大脑的某个区域，也可能是一种全身问题，不同的器官有不同的补偿能力。我们不相信所有的人都有一个缺点；相反，我们相信铁代谢中的几个问题最终会被发现导致这种综合征。本提案的长期目标是通过将中枢神经系统铁状态的变化与RLS患者临床方面的变化联系起来，确定脑铁代谢在RLS中的重要性；为RLS提供更好的治疗方法。在这项研究中，我们将重点放在静脉注射铁作为这种综合征的潜在长期治疗选择上。我们还解决了是否有铁流失增加的问题，以及铁处理是否可能存在铁过载或过度氧化应激的问题。

Our core concept is that RLS is related to an underlying problem in iron utilization. This may be specific to the brain or a region of the brain, or may be a general systemic problem with different organs having different abilities to compensate. We do not believe that there is one defect for all; rather, we believe that several problems in iron metabolism will eventually be found to contribute to this syndrome. The long-term goal of this proposal is to establish the importance of brain iron metabolism in RLS by relating changes in the CNS iron status to changes in the clinical aspects of RLS patients; and to provide improved treatment for RLS. In this grant we focus on the use of intravenous iron as a potential long-term treatment option for this syndrome. We also address the question of whether there is increased iron loss and whether there are likely to be problems of iron overload or excessive oxidative stress with iron treatment. The specific aims of the current proposal are: Aim 1. To evaluate the ability to sustain for 2 years the initial therapeutic benefit of 1,000 mg of IV iron with iron versus placebo "supplemental" therapy. Aim 2. To evaluate putative mechanisms behind the rapid decrease in ferritin following intravenous (IV) iron treatment of RLS patients. Aim 3. To determine possible adverse effects from the IV iron treatment. Aim 4. To explore the effects of supplemental IV iron on patients who are non-responders to the initial 1000-mg IV iron dose.