CSHL Conference on the Cell Cycle

描述(由申请者提供)：本次会议将包括当前关于真核基因转录及其调控的最令人兴奋的研究。会议将讨论该领域的下列关键主题：染色质及其修饰如何主动设定基因特异性转录水平；启动子识别复合体及其在指导转录起始中的功能；X射线结晶学和电子显微镜揭示的大分子转录复合体的结构和组织；转录共调控复合体及其在分化和发育过程中作为转录调控介体的作用；转录合成反应的步骤；以及新兴成像技术在活细胞转录实时分析中的应用。这次会议的目标是报告这些主题的最新进展，并提供对详细的转录调控机制以及转录调控如何与其他细胞和发育过程相结合的理解。 会议将集中讨论真核转录研究的最新进展，真核转录是在基因表达的第一步将DNA复制到RNA中的过程。转录及其以基因特有的方式进行的调控是所有生物学的核心。许多遗传性疾病和癌症是由转录调控异常引起的。

DESCRIPTION (provided by applicant): This meeting will encompass the most exciting current research on eukaryotic mRNA transcription and its regulation. Sessions will address the following pivotal topics in the field: how chromatin and its modification actively sets levels of gene-specific transcription; promoter recognition complexes and their function in directing transcription initiation; the structure and organization of large macromolecular transcription complexes as revealed by X-ray crystallography and electron microscopy; transcriptional coregulatory complexes and their roles as mediators of transcriptional regulation during differentiation and development; the steps in the transcript synthesis reaction; and the application of emerging imaging techniques to the real time analysis of transcription in living cells. The goals of this meeting are to report the most recent progress on these topics, as well as to provide an understanding of both detailed transcriptional regulatory mechanisms and how transcriptional regulation integrates with other cellular and developmental processes. The meeting will focus on recent advances in the study of eukaryotic transcription, which is the process of copying DNA into RNA during the first step of gene expression. Transcription and its regulation in a gene specific fashion are central to all of biology. Many genetic diseases and cancers result from aberrant transcriptional regulation.