CSHL Conference on Channels, Receptors, Synapses

描述(申请人提供)：“通道、受体、突触”冷泉港实验室会议，2006年4月18-22日。关于“通道、受体、突触”的会议将召集该领域的领导者，以及初级教师、博士后研究员和研究生，讨论神经兴奋性和突触功能的分子控制方面的新的前沿发展。本申请书寻求对将于2006年4月在冷泉港实验室举行的会议以及2008-2010年的后续会议的支持。 离子通道和受体是控制膜兴奋性和在大脑神经元之间的突触处介导信号传递的关键分子。2006年会议将讨论的议题包括：1)通道和受体功能的调节；2)突触形成的发展和调节；3)突触可塑性的分子机制及其在脑功能中的作用；4)离子通道/受体在人类疾病中的参与。 会议将采用不同的技术方法(包括细胞生物学、遗传学、生物化学、电生理学和行为学)，并将展示一系列实验系统(从哺乳动物到无脊椎动物模型生物)。这次会议的一个重要使命是跨越该领域的全光谱，从离子通道/受体的结构-功能的简化论研究到脑功能的活体研究。疾病的分子发病机制将得到强调，因为越来越明显的是，通道、受体和突触的功能障碍往往是导致或间接参与神经系统疾病的原因。 每期会议将由该领域的一位顶尖科学家主持。口头发言将从会议主席与组织者协商后提交的摘要中挑选出来。选定的演讲者将包括研究生、博士后研究员和初级教职员工，旨在最大限度地纳入初级调查人员。特别重要的是两个海报会议，许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。将举办两场专题讲座，重点介绍重要或快速发展的领域。这次会议将是中等规模的，我们预计将有大约300人参加，其中绝大多数人将展示海报或演讲。随后每两年举行一次的会议将采用类似的形式，并将包括与会议时高度相关的议题。

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on "Channels, Receptors, Synapses," April 18-22, 2006. The meeting on "Channels, Receptors, Synapses" will assemble the leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss new, cutting-edge developments in the molecular control of neuronal excitability and synapse function. This application seeks support for the meeting which will be held at Cold Spring Harbor Laboratory April, 2006 and the subsequent conferences in 2008-2010. Ion channels and receptors are the key molecules that control membrane excitability and mediate signaling at synapses between neurons in the brain. Topics to be discussed for the 2006 meeting include: 1) Modulation of channel and receptor function; 2) The development and regulation of synapse formation; 3) The molecular mechanisms of synaptic plasticity and their roles in brain function; 4) The involvement of ion channels/receptors in human disease. The meeting will embrace diverse technical approaches (including cell biology, genetics, biochemistry, electrophysiology and behavior) and will showcase a range of experimental systems (from mammals to invertebrate model organisms). An important mission of the conference is to span the full spectrum of this field from reductionist studies of the structure-function of ion channels/receptors to in vivo investigations of brain function. The molecular pathogenesis of disease will be highlighted, since it is becoming increasingly apparent that dysfunction of channels, receptors and synapses are often causally or indirectly involved in nervous system disorders. Each session will be chaired by a leading scientist in the field. Oral presentations will be selected from submitted abstracts by the session chairs in consultation with the organizers. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of junior investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. Two special lectures will be presented to highlight important or rapidly moving areas. The meeting will be of moderate size and we expect about 300 people to attend, the vast majority of whom will be presenting a poster or talk. The subsequent biennially conferences will follow a similar format and will include topics that are highly relevant at the time of the meeting.