Phylogeny of Sleep

睡眠的系统发育

基本信息

  • 批准号:
    7009306
  • 负责人:
  • 金额:
    $ 31.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-01-20 至 2007-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): About 70 million Americans suffer from a sleep problem; among them, nearly 60 percent have a chronic sleep disorder. Sleep disorders account for approximately $16 Billion of the annual US health care bill, yet basic questions about the functions and evolution of sleep remain unanswered and understudied. The purpose of this proposal is to investigate the distinct evolutionary histories and physiological functions of the two major mammalian sleep states REM (rapid eye movement or active sleep) and NREM (non-REM or quiet sleep) using state of the art analytic procedures for assessment of phylogenetic change. Such an investigation would clarify the role of each of the sleep states in the restorative capacities of sleep and would illuminate the ways in which breakdowns in the separate functions of each sleep state could lead to clinical disorders of sleep. Our approach is to use phylogeny-based comparative analysis to examine how, and in association with which other traits, REM and NREM evolved. Research during the past two decades has produced major advances in understanding sleep within particular species. Simultaneously, molecular advances have made it possible to generate phylogenetic trees, while new analytical methods provide the tools to examine macroevolutionary change on these trees. Thus, comparative methodology has entered a new "Golden Age" - but these methods have yet to be applied to questions concerning the evolution of distinctive sleep state functions. Our specific aims are to 1) Develop a Web-accessible comparative database on mammalian sleep patterns. Exhaustive literature searches have shown that quality data on sleep quotas is now available for approximately 150 species. We present analyses in this re-submittal that show that data on sleep quotas that were obtained over the past few decades in the laboratory are generally reliable and valid indices of sleep processes as they occur in the wild. Investigators who collected these data made strenuous efforts when recording sleep values to approximate natural conditions for the animals under study. Our other aims involve analyses of the data set constructed under Aim 1. These aims include 2) Investigate allometric trends, quantify phylogenetic signal and identify confounding variables. 3) Test a priori hypotheses for the evolution of and functions of active/REM versus quiet non-REM Sleep: 4) Develop a cost-benefit model of sleep states: Development of a cost-benefit model of sleep will allow us to further explore independent functions of REM/NREM and to derive clinical implications of perturbations in sleep durations of the two sleep states that typically occur in major human sleep disorders.
描述(申请人提供):约7000万美国人患有睡眠问题,其中近60%患有慢性睡眠障碍。睡眠障碍约占美国每年医疗保健账单的160亿美元,然而关于睡眠功能和进化的基本问题仍然没有得到回答,也没有得到充分的研究。这一建议的目的是利用最先进的分析程序来评估系统发育变化,以研究哺乳动物两种主要睡眠状态REM(快速眼动或活跃睡眠)和NREM(非REM或安静睡眠)的不同进化历史和生理功能。这样的研究将阐明每种睡眠状态在睡眠恢复能力中的作用,并将阐明每种睡眠状态的单独功能崩溃可能导致临床睡眠障碍的方式。我们的方法是使用基于系统发育的比较分析来研究REM和NREM是如何进化的,以及与哪些其他性状相关联。在过去的二十年里,研究在理解特定物种的睡眠方面取得了重大进展。同时,分子的进步使构建系统发育树成为可能,而新的分析方法提供了检查这些树的宏观进化变化的工具。因此,比较方法论进入了一个新的“黄金时代”--但这些方法尚未被应用于有关独特睡眠状态功能进化的问题。我们的具体目标是:1)开发一个可通过网络访问的哺乳动物睡眠模式比较数据库。详尽的文献搜索表明,关于睡眠定额的高质量数据现在可用于大约150个物种。我们在此重新提交的分析表明,过去几十年在实验室获得的睡眠定额数据通常是在野外发生的睡眠过程的可靠和有效指标。收集这些数据的研究人员在记录睡眠值以接近被研究动物的自然条件时做出了艰苦的努力。我们的其他目标包括分析在目标1下构建的数据集。这些目标包括2)调查异速生长趋势、量化系统发育信号和识别混淆变量。3)检验活跃/快速眼动睡眠与安静非快速眼动睡眠的演化和功能的先验假设:4)开发睡眠状态的成本效益模型:睡眠成本效益模型的发展将使我们能够进一步探索快速眼动/非快速眼动睡眠的独立功能,并推导出两种睡眠状态的睡眠持续时间扰动的临床意义,这两种睡眠状态通常发生在人类主要睡眠障碍中。

项目成果

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PATRICK J MCNAMARA其他文献

PATRICK J MCNAMARA的其他文献

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{{ truncateString('PATRICK J MCNAMARA', 18)}}的其他基金

SLEEP TRAJECTORIES IN PARKINSON'S DISEASE
帕金森病的睡眠轨迹
  • 批准号:
    7606260
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
Pragmatic language skills in patients with Parkinson's Disease (PD)
帕金森病 (PD) 患者的实用语言技能
  • 批准号:
    7587951
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
REM and NREM Processing Specializations
REM 和 NREM 加工专业化
  • 批准号:
    7498568
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
Pragmatic language skills in patients with Parkinson's Disease (PD)
帕金森病 (PD) 患者的实用语言技能
  • 批准号:
    7251328
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
REM and NREM Processing Specializations
REM 和 NREM 加工专业化
  • 批准号:
    7305376
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
Pragmatic language skills in patients with Parkinson's Disease (PD)
帕金森病 (PD) 患者的实用语言技能
  • 批准号:
    7391241
  • 财政年份:
    2007
  • 资助金额:
    $ 31.88万
  • 项目类别:
TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK
牛奶中的转运基因表达和药物积累
  • 批准号:
    7607340
  • 财政年份:
    2006
  • 资助金额:
    $ 31.88万
  • 项目类别:
TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK
牛奶中的转运基因表达和药物积累
  • 批准号:
    7379029
  • 财政年份:
    2006
  • 资助金额:
    $ 31.88万
  • 项目类别:
Phylogeny of Sleep
睡眠的系统发育
  • 批准号:
    6875314
  • 财政年份:
    2005
  • 资助金额:
    $ 31.88万
  • 项目类别:
Phylogeny of Sleep
睡眠的系统发育
  • 批准号:
    7209005
  • 财政年份:
    2005
  • 资助金额:
    $ 31.88万
  • 项目类别:

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