TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK

牛奶中的转运基因表达和药物积累

• 批准号: 7607340
• 负责人: PATRICK J MCNAMARA
• 金额: $ 0.23万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607340
• 关键词: Cell model; Cimetidine; Class; Computer Retrieval of Information on Scientific Projects Database; Development; Drug Transport; Epithelial Cells; Funding; Future; Gene Expression; Genes; Goals; Grant; Human; Human Milk; Institution; Mammary gland; Milk; Nitrofurantoin; Pharmaceutical Preparations; Protocols documentation; Research; Research Personnel; Resources; Role; Source; System; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the protocol is to systematically evaluate the role of genes in the accumulation of drugs into human milk. By identifying which transporters are present in mammary epithelial cells we hope to establish not only the identity of transporters for nitrofurantoin and cimetidine, but to focus future studies on those classes of drugs likely to accumulate into milk. Functional studies will substantiate the role of these expressed transporters in the specific accumulation of nitrofurantoin and cimetidine. The further development of a model cell system that mimics the human mammary epithelial cell barrier will significantly enhance our understanding of the mechanisms of drug transport into milk.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该方案的目标是系统地评估基因在药物积累到人乳中的作用。通过确定哪些转运蛋白存在于乳腺上皮细胞中，我们希望不仅能确定呋喃妥因和西咪替丁转运蛋白的身份，而且将未来的研究重点放在那些可能积累到乳汁中的药物类别上。功能研究将证实这些表达的转运蛋白在呋喃妥因和西咪替丁特异性蓄积中的作用。进一步开发模拟人乳腺上皮细胞屏障的模型细胞系统将显著增强我们对药物转运至乳汁中的机制的理解。