Pragmatic language skills in patients with Parkinson's Disease (PD)

帕金森病 (PD) 患者的实用语言技能

• 批准号: 7251328
• 负责人: PATRICK J MCNAMARA
• 金额: $ 39.34万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251328
• 关键词: Accounting; Affect; Affective; Age; Arts; Behavior; Behavior Disorders; Behavioral; Benchmarking; Biometry; Boston; California; Caregiver Burden; Clinical; Clinical Treatment; Cognitive; Cognitive deficits; Collaborations; Communication; Communication impairment; Competence; Comprehension; Corpus striatum structure; Data; Data Analyses; Diagnosis; Disease; Disease Progression; Disease regression; Dose; Exhibits; Functional disorder; Hamilton Rating Scale for Depression; Impairment; Individual; Language; Language Disorders; Left; Levodopa; Linguistics; Link; Longitudinal Studies; Measurement; Measures; Mediation; Mental Depression; Methods; Modeling; Moods; Motor; NIH Program Announcements; Natural History; Nature; Neurobiology; Neurology; Neuropharmacology; Neuropsychology; Newly Diagnosed; Parkinson Disease; Patients; Pattern; Pharmaceutical Preparations; Pilot Projects; Process; Production; Prospective Studies; Psyche structure; Range; Rate; Reaction Time; Relative (related person); Reporting; Research; Research Design; Research Personnel; Role; Schizophrenia; Science; Score; Series; Severity of illness; Side; Social Environment; Social Functioning; Social Interaction; Specialist; Speech; Staging; Statistically Significant; System; Techniques; Testing; Thinking; Time; Universities; cognitive function; daily functioning; disability; dosage; language processing; medical schools; neurobehavioral; neuropathology; neuropsychological; novel; programs; psychologic; relating to nervous system; response; skills; social; social communication; social skills

DESCRIPTION (provided by applicant): Language disorders in Parkinson's disease (PD) are a) more frequent than previously suspected, b) under- diagnosed and under-treated and c) increase disability and caregiver burden when present - yet no properly controlled, prospective studies of language problems in PD have yet been conducted. We propose to conduct just such a longitudinal study of language changes in PD and to assess the impact of these changes on daily functioning in affected patients. We will focus on "pragmatic" language processes as these concern the use of language in social context and recent reports (McNamara & Durso, 2003) document significant deficits in selected aspects of pragmatic language processing in mid-stage PD patients. We will test the hypothesis that pragmatic language/communication skills are impaired even in early PD and are significantly related to cognitive, affective (e.g., depression) and social dysfunction associated with PD. We propose a longitudinal research design assessing language functions as well as cognitive, affective and social functions in a group of 54 newly diagnosed PD patients. Patients will be assessed three times over the course of the 5-year study (approximately every 1.5 years). Mixed effects regression modeling will be applied to the data to derive quantitative estimates of key indicators of language trajectories of PD patients and the relations of these trajectories to changes in disease severity, medication dosing regimes, cognitive, affective and social functions. Data from this project will 1) give us a clear picture of the nature of the pragmatic deficit in PD as well as its cognitive and neuropsychological correlates; 2) clarify the role neo-striatal/prefrontal neural systems in mediation of pragmatic functions; 3) clarify the extent to which pragmatic social communication deficits are related to the cognitive and social deficits of PD; and 4) establish benchmark data on neural, cognitive and affective correlates of fundamental pragmatic functions which could potentially be used to develop more effective clinical treatments for disorders of social communication.

描述（由申请人提供）：帕金森病 (PD) 中的语言障碍 a) 比以前怀疑的更为常见，b) 诊断不足和治疗不足，c) 存在时会增加残疾和护理人员负担 - 但尚未对帕金森病中的语言问题进行适当控制的前瞻性研究。我们建议对帕金森病患者的语言变化进行这样的纵向研究，并评估这些变化对受影响患者日常功能的影响。我们将重点关注“语用”语言过程，因为这些过程涉及社会环境中语言的使用，最近的报告（McNamara & Durso，2003）记录了中期 PD 患者语用语言处理的某些方面存在显着缺陷。我们将检验以下假设：即使在早期帕金森病中，语用语言/沟通技能也会受到损害，并且与帕金森病相关的认知、情感（例如抑​​郁）和社会功能障碍显着相关。我们提出了一项纵向研究设计，评估 54 名新诊断 PD 患者的语言功能以及认知、情感和社交功能。在为期 5 年的研究过程中，患者将接受 3 次评估（大约每 1.5 年一次）。混合效应回归模型将应用于数据，以得出 PD 患者语言轨迹关键指标的定量估计，以及这些轨迹与疾病严重程度、药物剂量方案、认知、情感和社会功能变化的关系。该项目的数据将 1) 让我们清楚地了解 PD 语用缺陷的本质及其认知和神经心理学相关性； 2）阐明新纹状体/前额神经系统在调节语用功能中的作用； 3）阐明语用社交沟通缺陷与PD认知和社交缺陷的相关程度； 4) 建立基本语用功能的神经、认知和情感相关性的基准数据，这些数据有可能用于开发更有效的社交沟通障碍临床治疗方法。