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Pragmatic language skills in patients with Parkinson's Disease (PD)

帕金森病 (PD) 患者的实用语言技能

基本信息

批准号：
7587951
负责人：
PATRICK J MCNAMARA
金额：
$ 49.09万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-01 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7587951
关键词：
Accounting Affect Affective Age Arts Behavior Behavior Disorders Behavioral Benchmarking Biometry Boston California Caregiver Burden Clinical Clinical Treatment Cognitive Cognitive deficits Collaborations Communication Communication impairment Competence Comprehension Corpus striatum structure Data Data Analyses Diagnosis Disease Disease Progression Dose Exhibits Functional disorder Hamilton Rating Scale for Depression Impairment Individual Language Language Disorders Left Levodopa Linguistics Link Longitudinal Studies Measurement Measures Mediation Methods Modeling Moods Motor NIH Program Announcements Natural History Nature Neurobiology Neurology Neuropharmacology Neuropsychology Newly Diagnosed Parkinson Disease Patients Pattern Pharmaceutical Preparations Pilot Projects Process Production Prospective Studies Psyche structure Reaction Time Relative (related person)Reporting Research Research Design Research Personnel Role Schizophrenia Science Series Severity of illness Side Social Environment Social Functioning Social Interaction Specialist Speech Staging System Techniques Testing Thinking Time Universities cognitive function daily functioning depression disability dosage language processing medical schools neurobehavioral neuropathology neuropsychological novel phrases programs psychologic relating to nervous system response skills social social communication social skills

项目摘要

DESCRIPTION (provided by applicant): Language disorders in Parkinson's disease (PD) are a) more frequent than previously suspected, b) under- diagnosed and under-treated and c) increase disability and caregiver burden when present - yet no properly controlled, prospective studies of language problems in PD have yet been conducted. We propose to conduct just such a longitudinal study of language changes in PD and to assess the impact of these changes on daily functioning in affected patients. We will focus on "pragmatic" language processes as these concern the use of language in social context and recent reports (McNamara & Durso, 2003) document significant deficits in selected aspects of pragmatic language processing in mid-stage PD patients. We will test the hypothesis that pragmatic language/communication skills are impaired even in early PD and are significantly related to cognitive, affective (e.g., depression) and social dysfunction associated with PD. We propose a longitudinal research design assessing language functions as well as cognitive, affective and social functions in a group of 54 newly diagnosed PD patients. Patients will be assessed three times over the course of the 5-year study (approximately every 1.5 years). Mixed effects regression modeling will be applied to the data to derive quantitative estimates of key indicators of language trajectories of PD patients and the relations of these trajectories to changes in disease severity, medication dosing regimes, cognitive, affective and social functions. Data from this project will 1) give us a clear picture of the nature of the pragmatic deficit in PD as well as its cognitive and neuropsychological correlates; 2) clarify the role neo-striatal/prefrontal neural systems in mediation of pragmatic functions; 3) clarify the extent to which pragmatic social communication deficits are related to the cognitive and social deficits of PD; and 4) establish benchmark data on neural, cognitive and affective correlates of fundamental pragmatic functions which could potentially be used to develop more effective clinical treatments for disorders of social communication.

描述（由申请人提供）：帕金森病（PD）中的语言障碍a）比之前怀疑的更常见，B）诊断不足和治疗不足，c）存在时会增加残疾和护理人员负担-但尚未进行适当控制的帕金森病语言问题的前瞻性研究。我们建议对PD的语言变化进行这样的纵向研究，并评估这些变化对受影响患者日常功能的影响。我们将重点关注“语用”的语言过程，因为这些涉及在社会背景下使用的语言和最近的报告（McNamara和Durso，2003年）文件显着缺陷，在选定的方面，中期PD患者的语用语言处理。我们将检验这一假设，即语用语言/沟通技能即使在早期PD也会受损，并且与认知、情感（例如，抑郁症）和与PD相关的社会功能障碍。我们提出了一个纵向研究设计评估语言功能以及认知，情感和社会功能在一组54例新诊断的PD患者。在5年研究期间，将对患者进行3次评估（约每1.5年一次）。混合效应回归模型将应用于数据，以获得PD患者语言轨迹关键指标的定量估计值，以及这些轨迹与疾病严重程度、药物给药方案、认知、情感和社会功能变化的关系。本研究的数据将使我们对PD的语用功能缺陷的本质及其认知和神经心理学的相关性有一个清晰的认识：2）阐明新纹状体/前额叶神经系统在语用功能调节中的作用; 3）阐明PD的语用社交缺陷与认知和社交缺陷的关系;（4）建立基本语用功能的神经、认知和情感相关性的基准数据，这些数据可能用于开发更有效的临床治疗社交障碍的方法。