REM and NREM Processing Specializations

REM 和 NREM 加工专业化

• 批准号: 7498568
• 负责人: PATRICK J MCNAMARA
• 金额: $ 20.31万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7498568
• 关键词: Blinded; Cognitive; Dreams; Emotional; Emotions; Exhibits; Home environment; Lead; Mind; Modeling; Numbers; Operative Surgical Procedures; Pattern; Polysomnography; Process; Psyche structure; Purpose; REM Sleep; Reporting; Research; Sleep; Sleep Disorders; Social Interaction; Source; Techniques; Testing; follow-up; mental health related disorder; non rapid eye movement; programs; rapid eye movement; research study; simulation; theories; volunteer

DESCRIPTION (provided by applicant): The purpose of this R21 proposal is to develop a new research program that will explore potential cognitive processing specializations of REM (rapid eye movement) and NREM (non-REM) sleep states. Identifying such processing specializations would point to hitherto unrecognized correlates of functional specializations for REM and NREM and thus may lead to a breakthrough in our understanding of sleep function. In a recent (McNamara, McLaren, Smith, Brown, & Stickgold, 2005) analysis of over 500 mentation reports from the REM, NREM and wake states, we found that REM exhibited greater numbers of simulations of aggressive social interactions than NREM or waking reports, and NREM exhibited greater numbers of simulations of friendly interactions than REM or wake reports. Indeed, there were absolutely no (zero) simulations of aggressive interactions in NREM reports. We plan to follow-up on and extend these findings by performing overnight polysomnographic recordings along with REM and NREM awakenings in a group of healthy young volunteers. We will explore the following questions in the proposed experiments: 1) Can the McNamara et al. (2005) findings be replicated and extended? Is there any evidence for REM and NREM cognitive processing specializations with respect to a) simulations of social interactions, b) emotions, and c) attributions of intentional states to other dream characters ("Theory of Mind") and 2) Is content of a NREM "dream" related to the content of a REM "dream" across a single night of sleep? Identifying cognitive processing specializations of REM and NREM sleep will yield better quantitative models of a variety of sleep disorders and better treatment of sleep-related mental health disorders.

描述（由申请人提供）：该 R21 提案的目的是开发一项新的研究计划，该计划将探索 REM（快速眼动）和 NREM（非 REM）睡眠状态的潜在认知处理专业化。识别这种处理专门化将指出迄今为止尚未认识到的 REM 和 NREM 功能专门化的相关性，从而可能导致我们对睡眠功能理解的突破。最近（McNamara、McLaren、Smith、Brown 和 Stickgold，2005）对来自 REM、NREM 和清醒状态的 500 多个心理报告进行了分析，我们发现 REM 比 NREM 或清醒报告表现出更多数量的攻击性社交互动模拟，而 NREM 比 REM 或清醒报告表现出更多数量的友好互动模拟。事实上，NREM 报告中绝对没有（零）模拟攻击性相互作用。我们计划通过对一组健康的年轻志愿者进行夜间多导睡眠图记录以及快速眼动和非快速眼动觉醒来跟踪和扩展这些发现。我们将在拟议的实验中探讨以下问题：1）McNamara 等人可以吗？ (2005) 研究结果是否可以重复和扩展？是否有任何证据表明 REM 和 NREM 认知处理专业化涉及以下方面：a）社交互动的模拟，b）情绪，c）将意向状态归因于其他梦境角色（“心理理论”）以及 2）NREM“梦”的内容与单晚睡眠中的 REM“梦”的内容相关吗？识别快速眼动睡眠和非快速眼动睡眠的认知处理专门化将为各种睡眠障碍提供更好的定量模型，并更好地治疗与睡眠相关的心理健康障碍。

项目成果

Impact of REM sleep on distortions of self-concept, mood and memory in depressed/anxious participants.

• DOI: 10.1016/j.jad.2009.06.030
• 发表时间: 2010-05
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: McNamara, Patrick;Auerbach, Sanford;Johnson, Patricia;Harris, Erica;Doros, Gheorghe
• 通讯作者: Doros, Gheorghe

Sleep in Parkinson's disease: a comparison of actigraphy and subjective measures.

• DOI: 10.1016/j.parkreldis.2010.02.001
• 发表时间: 2010-05
• 期刊: Parkinsonism & related disorders
• 影响因子: 4.1
• 作者: Stavitsky K;Saurman JL;McNamara P;Cronin-Golomb A
• 通讯作者: Cronin-Golomb A

Sleep architecture and sleep-related mentation in securely and insecurely attached people.

安全依恋和不安全依恋的人的睡眠结构和睡眠相关的心理状态。

• DOI: 10.1080/14616734.2011.553999
• 发表时间: 2011
• 期刊: Attachment & human development
• 影响因子: 3.2
• 作者: McNamara,Patrick;Pace-Schott,EdwardF;Johnson,Patricia;Harris,Erica;Auerbach,Sanford
• 通讯作者: Auerbach,Sanford