TRANSPORT GENE EXPRESSION AND DRUG ACCUMULATION IN MILK

牛奶中的转运基因表达和药物积累

• 批准号: 7379029
• 负责人: PATRICK J MCNAMARA
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379029
• 关键词: TRANSPORT; GENE; EXPRESSION; DRUG; ACCUMULATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the protocol is to systematically evaluate the role of genes in the accumulation of drugs into human milk. By identifying which transporters are present in mammary epithelial cells we hope to establish not only the identity of transporters for nitrofurantoin and cimetidine, but to focus future studies on those classes of drugs likely to accumulate into milk. Functional studies will substantiate the role of these expressed transporters in the specific accumulation of nitrofurantoin and cimetidine. The further development of a model cell system that mimics the human mammary epithelial cell barrier will significantly enhance our understanding of the mechanisms of drug transport into milk.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该方案的目标是系统地评估基因在药物进入母乳中积累过程中的作用。通过确定乳腺上皮细胞中存在哪些转运体，我们希望不仅确定呋喃妥因和西咪替丁的转运体的身份，而且将未来的研究重点放在那些可能积聚到牛奶中的药物类别上。功能研究将证实这些表达的转运体在呋喃妥因和西咪替丁的特定积累中所起的作用。模拟人类乳腺上皮细胞屏障的模型细胞系统的进一步发展将极大地增强我们对药物进入牛奶的机制的理解。