Autonomic Control & Birth Outcomes in Minority Women

自主控制

• 批准号: 7095391
• 负责人: Richard P SLOAN
• 金额: $ 9.3万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-10 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095391
• 关键词: African American; autonomic nervous system; behavioral /social science research tag; blood pressure; cardiovascular function; caucasian American; female; gestational age; health disparity; heart rate; human data; low birth weight infant human; military personnel; neuroregulation; pregnancy disorder; premature infant human; psychological stressor; racial /ethnic difference; social psychology; women' s health

DESCRIPTION (provided by applicant): Preterm birth is a major cause of perinatal morbidity and mortality but its causes are only poorly understood. The problems are particularly significant for African-Americans, who are twice as likely as Caucasians to experience the death of an infant under one year old and to have a baby born preterm. While some evidence implicates psychosocial stress and the related autonomic nervous system dysfunction as a pathophysiologic factor, little is known about their roles in adverse pregnancy outcomes. The overall aim of this application for an exploratory grant is to examine the role of the ANS, psychosocial stress, and racial differences as they relate to duration of gestation and birth weight. From 1996 to 2001, data were collected from 683 pregnant military women stationed at Lackland Air Force Base. In 390 of these subjects, heart rate and blood pressure responses to standard laboratory stressors were measured during the second trimester to determine if responsiveness to these stressors predicted adverse birth outcomes. We used this opportunity to collect, digitize, and archive continuous electrocardiographic, blood pressure, and respiratory waveforms for later analysis of heart rate and blood pressure variability and baroreflex sensitivity, indices of autonomic regulation that are considerably more sensitive than heart rate and blood pressure. Support for analysis of the autonomic data was not provided by the Department of Defense project. These archived data provide us with an unprecedented opportunity to conduct exploratory analyses using more sensitive indices to characterize autonomic regulation of the cardiovascular system at rest and in response to standardized laboratory stressors during pregnancy in a large sample of military women who are homogeneous with respect to many potentially confounding variables relevant to birth outcomes, e.g., physical health, employment status, health behaviors, and access to prenatal care. Using this existing dataset, we propose to explore the role of the autonomic nervous system in premature delivery and low birth weight in general, and more specifically, how stress-related autonomic dysregulation may contribute to the substantially elevated risk of poor birth outcomes in African American women.

描述（由申请人提供）：早产是围产期发病率和死亡率的主要原因，但其原因只能理解。对于非裔美国人来说，问题尤其重要，非裔美国人的可能性是高加索人的两倍以下婴儿死亡，并有一个婴儿出生的早产。尽管一些证据暗示了社会心理压力和相关的自主神经系统功能障碍是一种病理生理因素，但对它们在不良怀孕结局中的作用知之甚少。该应用程序对探索性赠款的总体目的是研究ANS，社会心理压力和种族差异的作用，因为它们与妊娠持续时间和出生体重有关。从1996年到2001年，从驻扎在拉克兰空军基地的683名怀孕的军事妇女那里收集了数据。在这些受试者的390个受试者中，对标准实验室压力源的心率和血压反应在妊娠中期进行了测量，以确定对这些压力源的反应是否预测了不良出生结果。我们利用这一机会来收集，数字化和存档连续心电图，血压和呼吸波形，以后分析心率和血压变异性以及压力反射敏感性，自主神经调节指标的敏感性比心率和血压更为敏感。国防部项目未提供对自主数据分析的支持。这些存档的数据为我们提供了前所未有的机会，可以使用更敏感的指标进行探索性分析，以表征静止的心血管系统的自主性调节，并响应在怀孕期间对标准化的实验室压力源的响应，在大量的军事妇女中，这些妇女在许多潜在的潜在的差异与生物相关的同性恋均与身体健康相关，并以健康状态，以及健康的健康状况。我们建议使用此现有数据集，探讨自主神经系统在过早分娩中的作用，总体而言，更具体地说，与压力相关的自主性失调如何有助于非洲裔美国妇女出生不良的风险显着升高。