Biomarkers of Stress and Health for Los Angeles Children

描述(申请人提供)：在这个项目中，我们建议将0-17岁儿童压力和健康的生物标记物集合添加到正在进行的对儿童、家庭和社区的纵向研究中。这项研究是洛杉矶家庭和邻里调查(L.A.FANS)，其设计通过收集关于社区、家庭、成年人和儿童的纵向数据，以及关于居住选择和社区变化的数据，补救了许多限制了先前关于社区影响研究的问题。第一波(L.A.FANS-1)于2002年1月完成，访问了居住在3090户家庭中的成年人和儿童，调查对象为洛杉矶县65个社区的不同分层概率样本。计划于2005-2006年开展的第二波活动(L.A.FANS-2)由NICHD和NIA提供资金，包括收集样本中成年人的压力和健康生物标记物、关于成人和儿童及其照顾者的问卷数据以及关于社区社会和身体状况的信息。作为该项目的一部分(L.A.FANS-2/CB-“儿童生物标记物”)，我们建议通过开展实地工作来补充第二波数据收集，为样本中所有0-17岁的儿童收集类似的压力和健康生物标记物。数据收集将与L.A.FANS-2主要调查同时进行，这将提高效率和降低成本。这些数据将为研究邻里和家庭环境对儿童健康和福祉的影响提供重要的新资源。 本项目的具体目标是：(1)收集洛杉矶FANS-2所有儿童的应激、疾病和健康的生理标记物，包括肥胖、皮质醇(应激激素)、血压、C反应蛋白(急性炎症的标记物)、爱泼斯坦-巴尔病毒抗体(免疫功能的标记物)、胆固醇、糖尿病和肺功能；(2)将这些数据与L.A.FANS-1和L.A.FANS-2数据一起放入公共领域，以供研究界在各种分析中使用；以及(3)为有兴趣使用这些数据的研究界提供支持。 作为该项目的一部分，在L.A.FANS-2/CB中收集的儿童生物标记物数据以及其他L.A.FANS数据将为广泛的研究人员提供重要的新资源，以调查社会因素对儿童压力、疾病和健康的影响。

DESCRIPTION (provided by applicant): In this project, we propose to add the collection of biomarkers of stress and health for children aged 0-17 to an ongoing longitudinal study of children, families, and neighborhoods. The study is the Los Angeles Family and Neighborhood Survey (L.A.FANS), whose design remedies many of the problems that have limited previous research on neighborhood effects, by collecting longitudinal data on neighborhoods, families, adults, and children, and on residential choice and neighborhood change. The first wave (L.A.FANS-1), completed in January 2002, interviewed adults and children living in 3,090 households in a diverse stratified probability sample of 65 neighborhoods throughout Los Angeles County. The second wave (L.A.FANS-2), planned for 2005-2006, has been funded by NICHD and NIA and includes the collection of biomarkers of stress and health for adults in the sample, questionnaire-based data on adults and on children and their caregivers, as well as information on neighborhood social and physical conditions. As part of this project (L.A.FANS-2/CB-for "child biomarkers"), we propose to supplement Wave 2 data collection by undertaking fieldwork to collect similar biomarkers of stress and health for all children aged 0-17 in the sample. Data collection will be conducted simultaneously with the main L.A.FANS-2 survey, which will promote efficiency and reduce costs. These data will provide a major new resource for studying the effects of neighborhood and family environments on children's health and well-being. The specific aims of this project are to: (1) Collect physiological markers of stress, disease, and health, including obesity, cortisol (a stress hormone), blood pressure, C-reactive protein (a marker of acute inflammation), Epstein-Barr virus antibodies (a marker of immune function), cholesterol, diabetes, and pulmonary function for all children in L.A.FANS-2; (2) Produce a well-documented data set from these data which, along with the L.A.FANS-1 and L.A.FANS-2 data, will be placed in the public domain for the research community to use in a variety of analyses; and (3) Provide support to the research community interested in using these data. The child biomarker data collected in L.A.FANS-2/CB as part of this project along with other L.A.FANS data will provide an important new resource for a wide range of researchers to investigate the effects of social factors on children's stress, disease, and health.