Integrated Tool for Biological Parametric Mapping

生物参数绘图集成工具

• 批准号: 7234335
• 负责人: Joseph A Maldjian
• 金额: $ 57.47万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234335
• 关键词: Affect; Analysis of Variance; Anatomy; Anisotropy; Aorta; Architecture; Area; Atlases; Auditory; Axon; Biochemistry; Biological; Biological Process; Brain; Brain imaging; Brodmann' s area; Bundling; Cell Density; Cell membrane; Chemicals; Choline; Clinical; Communication; Communities; Complement; Computer software; Data; Data Analyses; Data Set; Developmental reading disorder; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease regression; Dyslexia; Elements; Environment; Evaluation; Functional Imaging; Functional Magnetic Resonance Imaging; GDF15 gene; General Population; Goals; Image; Image Analysis; Imagery; Imaging Device; Individual; Informatics; Left; Licensing; Linear Models; Lobe; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manuals; Maps; Medicine; Modality; Multimodal Imaging; Neurons; Neurosciences Research; Numbers; PLAB Protein; Pathway interactions; Pattern; Phase; Picture Archiving and Communication System; Positron-Emission Tomography; Prevalence; Process; Published Comment; Reading; Research; Research Personnel; Schedule; Score; Sensory; Sensory Process; Signal Transduction; Site; Software Tools; Solutions; Source Code; Spectrum Analysis; Speed; Study Subject; Systems Integration; Techniques; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Value Meaning; Visual; base; cohort; data integration; density; design; digital imaging; experience; gray matter; interest; neurobehavioral disorder; neuroinformatics; programs; relating to nervous system; research study; single photon emission computed tomography; spectroscopic imaging; tool; tool development; user-friendly; white matter; white matter change

DESCRIPTION (provided by applicant): The objective of this Phase I project is to provide the neuroscience research community with a unique investigative tool for the seamless real-time integration of data from emerging imaging modalities (fMRI, PET, SPECT, MRS, and diffusion imaging). This tool will allow analysis of an enormous array of biological processes involving multiple cross-platform modalities recording activation, stimulation, biochemistry and tissue contrast. The proposed tool is IDLSPM, a software solution created by the PI incorporating an advanced computational architecture for distributed processing, analysis and visualization of multimodal imaging data. In this application we propose to incorporate Biologic Parametric Mapping (BPM), a new form of functional imaging data analysis that will integrate the information available from multiple functional imaging modalities and combine them into a user-friendly highly extensible and scaleable software environment. The basic idea behind BPM is to allow the probing of functional imaging data using the results of any other form of functional imaging data. The IDLSPM project represents a complete brain imaging solution that will provide the functional imaging community with unparalleled computational capabilities, integrated neuroanatomic and cytoarchitectonic atlases, ease of use, and tight integration to native SPM, allowing rapid advancement in both research and clinical implementations of functional imaging. In the biologic portion of our effort we will apply the neuroinformatics tools developed in this project towards studying the neurofunctional correlates of dyslexia. Developmental dyslexia is a common neurobehavioral disorder affecting a large number of people. Despite the sizeable prevalence of the disorder, there is relatively little known about its neural basis. Recent multimodal imaging data has implicated the left occipitotemporal and temporoparietal areas as regions of abnormality in dyslexics. The tools developed in this project will be used to uncover the neural functional and chemical relationships of dyslexia using crossmodal sensory tasks, diffusion tensor imaging, and 3D spectroscopy. Our informatics goal is to l) extend the functionality of this tool into a multimodal imaging environment for fMRI, PET, SPECT, diffusion imaging, and 3D spectroscopy data, and 2) incorporate biologic parametric mapping capabilities for probing functional MR data with multimodal imaging data. The goal of the biologic element of our project is to use BPM to determine if diffusion and spectroscopy changes in the occipitotemporal and temporoparietal regions are related to functional MRI changes observed in cross-modal sensory processing in dyslexics.

描述(由申请者提供)：这个第一阶段项目的目标是为神经科学研究团体提供一个独特的研究工具，用于无缝实时集成来自新兴成像方式(fMRI、PET、SPECT、MRS和扩散成像)的数据。这一工具将允许分析大量的生物过程，包括记录激活、刺激、生化和组织对比的多种跨平台模式。建议的工具是IDLSPM，这是PI创建的一个软件解决方案，其中包含用于分布式处理、分析和可视化多模式成像数据的高级计算架构。在这项应用中，我们建议结合生物参数映射(BPM)，这是一种新的功能成像数据分析形式，它将整合来自多个功能成像模式的信息，并将它们合并到一个用户友好、高度可扩展和可扩展的软件环境中。BPM背后的基本思想是允许使用任何其他形式的功能成像数据的结果来探测功能成像数据。IDLSPM项目代表了一个完整的脑成像解决方案，它将为功能成像社区提供无与伦比的计算能力、集成的神经解剖学和细胞架构图谱、易用性以及与本地SPM的紧密集成，从而使功能成像的研究和临床实施都能快速发展。在我们努力的生物学部分，我们将应用在这个项目中开发的神经信息学工具来研究阅读障碍的神经功能相关性。发育性阅读障碍是一种常见的神经行为障碍，影响着大量的人。尽管这种疾病的患病率相当高，但人们对其神经基础知之甚少。最近的多模式成像数据表明，左侧枕颞区和颞顶区是阅读障碍患者的异常区域。在这个项目中开发的工具将用于通过跨模式感觉任务、扩散张量成像和3D光谱来揭示阅读障碍的神经功能和化学关系。我们的信息学目标是：L)将该工具的功能扩展到用于功能磁共振成像、正电子发射断层扫描、SPECT、扩散成像和3D光谱数据的多模式成像环境中，以及2)将生物参数映射功能与多模式成像数据结合在一起，以探测功能性磁共振数据。我们项目的生物元素的目标是使用BPM来确定枕颞区和颞顶区的扩散和波谱变化是否与阅读障碍患者在跨模式感觉加工中观察到的功能MRI变化有关。

项目成果

Response of arteriovenous malformations to gamma knife therapy evaluated with pulsed arterial spin-labeling MRI perfusion.

通过脉冲动脉自旋标记 MRI 灌注评估动静脉畸形对伽玛刀治疗的反应。

• DOI: 10.2214/ajr.10.5290
• 发表时间: 2011
• 期刊: AJR. American journal of roentgenology
• 作者: Pollock,JeffreyM;Whitlow,ChristopherT;Simonds,Justin;Stevens,EAndrew;Kraft,RobertA;Burdette,JonathanH;Maldjian,JosephA
• 通讯作者: Maldjian,JosephA

The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate?

• DOI: 10.1002/hbm.20732
• 发表时间: 2009-10
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Addicott, Merideth A.;Yang, Lucie L.;Peiffer, Ann M.;Burnett, Luke R.;Burdette, Jonathan H.;Chen, Michael Y.;Hayasaka, Satoru;Kraft, Robert A.;Maldjian, Joseph A.;Laurienti, Paul J.
• 通讯作者: Laurienti, Paul J.

Arterial spin-labeling in routine clinical practice, part 2: hypoperfusion patterns.

• DOI: 10.3174/ajnr.a1033
• 发表时间: 2008-08
• 期刊: AJNR. American journal of neuroradiology
• 作者: Deibler AR;Pollock JM;Kraft RA;Tan H;Burdette JH;Maldjian JA
• 通讯作者: Maldjian JA

Arterial spin-labeling in routine clinical practice, part 1: technique and artifacts.

• DOI: 10.3174/ajnr.a1030
• 发表时间: 2008-08
• 期刊: AJNR. American journal of neuroradiology
• 作者: Deibler AR;Pollock JM;Kraft RA;Tan H;Burdette JH;Maldjian JA
• 通讯作者: Maldjian JA

Fully automated processing of fMRI data in SPM: from MRI scanner to PACS.

SPM 中的 fMRI 数据全自动处理：从 MRI 扫描仪到 PACS。

• DOI: 10.1007/s12021-008-9040-z
• 发表时间: 2009
• 期刊: Neuroinformatics
• 影响因子: 3
• 作者: Maldjian,JosephA;Baer,AaronH;Kraft,RobertA;Laurienti,PaulJ;Burdette,JonathanH
• 通讯作者: Burdette,JonathanH