Uncovering Brain Anatomy/Function/Relationships using Biologic Parametric Mapping

使用生物参数映射揭示大脑解剖结构/功能/关系

• 批准号: 7020238
• 负责人: Joseph A Maldjian
• 金额: $ 11.91万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7020238
• 关键词: Uncovering; Brain; Anatomy; Function; Relationships

DESCRIPTION (provided by candidate): The objective of this supplement is to provide a structured year of research training to a clinical resident under the mentorship of a NIBIB funded investigator. The parent grant for this supplement is composed of two components: a neuroinformatics component and a biologic component. The neuroinformatics component of the parent grant will develop multiple toolboxes including a biologic parametric mapping toolbox (BPM) for the statistical analysis of multimodal image data to be used in the current supplement. In this supplement, the BPM toolbox will be used to perform a multiple variable regression analysis to evaluate age-related relationships between functional MRI activation and structural anatomy. The overarching hypothesis for Dr. Deibler's research project is that age-related changes in grey matter volume are predictive of functional brain activity in a regionally specific manner. This analysis will control for differences in grey matter concentration. Dr. Deibler will be trained in the use of the BPM toolbox and he will implement the analyses of the data using the neuroinformatics tools from the parent project. The educational training plan proposed for Dr. Deibler has four elements: 1) development of knowledge through didactic course work in statistics, neuroscience, as well as attending journal club meetings and institutional seminars; 2) mastery of brain imaging research skills through study design, data collection, and data analyses under mentor guidance; 3) introduction to basic neurophysiologic research in the Department of Neurobiology and Anatomy at Wake Forest University; and 4) training in research ethics and medical conduct.

描述（由候选人提供）： 本补充的目的是提供一个结构化的一年的研究培训，以指导下的NIBIB资助的研究人员的临床居民。这种补充的父母补助金由两部分组成：神经信息学部分和生物学部分。母基金的神经信息学部分将开发多个工具箱，包括生物参数映射工具箱（BPM），用于当前补充中使用的多模态图像数据的统计分析。在本补充中，BPM工具箱将用于执行多变量回归分析，以评价功能性MRI激活和结构解剖之间的年龄相关关系。Deibler博士的研究项目的首要假设是，与年龄相关的灰质体积变化可以以区域特定的方式预测大脑功能活动。该分析将控制灰质浓度的差异。Deibler博士将接受使用BPM工具箱的培训，他将实施 使用来自母项目的神经信息学工具分析数据。为Deibler博士提出的教育培训计划有四个要素：1）通过统计学、神经科学的教学课程工作以及参加期刊俱乐部会议和机构研讨会来发展知识; 2）在导师指导下通过研究设计、数据收集和数据分析来掌握脑成像研究技能; 3）介绍维克森林大学神经生物学和解剖学系的基础神经生理学研究; 4）研究伦理和医学行为培训。