Sports Related Subconcussive Impacts in Children: MRI & Biomechanical Correlates

儿童运动相关的亚脑震荡影响：MRI

• 批准号: 8748697
• 负责人: Joseph A Maldjian
• 金额: $ 7.46万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8748697
• 关键词: 12 year old; Area; Attention; Award; Behavior assessment; Biomechanics; Biomedical Engineering; Biometry; Brain; Brain Concussion; Child; Childhood; Childhood Injury; Clinical; Cognitive; Collaborations; Collection; Control Groups; Craniocerebral Trauma; Data; Data Analyses; Data Collection; Data Set; Databases; Diffusion; Diffusion Magnetic Resonance Imaging; Elements; Enrollment; Equipment; Funding; Grant; Head; Health Sciences; Human Resources; Image; Individual; Injury; Investments; Letters; Magnetic Resonance Imaging; Manufactured football; Measures; Mediating; Metric; Monitor; Neurocognitive; Neuropsychological Tests; Parents; Participant; Recording of previous events; Research; Research Personnel; Risk; Seasons; Sports; System; Technology; Telemetry; Testing; Time; Traumatic Brain Injury; United States National Institutes of Health; Universities; Weight; Work; Youth; age group; base; clinical epidemiology; college; data acquisition; experience; forest; graduate student; high school; instrument; member; neuroimaging; neuropsychological; prevent; public health relevance; research clinical testing

DESCRIPTION (provided by applicant): Title: Sports-related sub concussive impacts in children: MRI & biomechanical correlates Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional and collegiate levels, there is little data at the high school level and scarceif any data available for participants in the youth leagues (8-12 years old). This study will relate information about biomechanical forces experienced during a hit in youth football to neurocognitive and imaging data to determine the effects of subconcussive impacts. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI). In this R03 we will investigate the biomechanical and cognitive correlates of diffusion MRI scalar measures of mTBI in children. This project leverages the investments by Wake Forest University Health Sciences which has identified, instrumented and enrolled youth football players, and funded the data collection as part of our ongoing work in this area of critical public importance. We already have acquired a very rich data set of ~30 youth players (8- 12 years old) followed over the course of an entire season (2012 football season). All players were instrumented with the Head Impact Telemetry System (HITS) for collection of real-time impact data during all practices and games. Baseline, post-season and post-concussion multimodal magnetic resonance imaging (MRI), including structural T1-weighted, and diffusion tensor and kurtosis imaging (DTI/DKI) were performed in all subjects. Neurocognitive assessments using the pediatric Immediate Post-concussion Assessment and Cognitive Testing (ImPACT) were obtained at baseline, post-injury, and post-season. Data acquisition is now continuing into the 2013 season with 30 new players already being monitored with HITs, and having all received baseline imaging and neuropsychologic testing including IMPACT testing and additional NIH toolbox measures. We have also recently been awarded internal institutional funding for acquiring a non-contact sport control data set (25 participants), including imaging and cognitive testing at baseline and post-season. This R03 will help fund a graduate student in Biomedical Engineering to assist in the MRI diffusion analyses of the acquired youth football and control data. The utilization of state-of-the-art HITs technology and the acquisition of HITs data at all practices and games provides an extremely thorough characterization of the biomechanical forces experienced by the brains of the young athletes. This unique data set represents the largest of its type in the world, combining imaging, cognitive testing and biomechanical measures in the youth age group. The long term benefit of the research will be to allow equipment designers, researchers, and clinicians to better prevent, mitigate, identify and treat injuries to help make football a safer activity for millions of children.

描述（由申请人提供）：标题：儿童运动相关的亚震荡影响：MRI和生物力学相关性足球头部损伤涉及重大力量，并可能导致轻度至重度创伤性脑损伤。虽然这一点越来越受到关注， 在专业和大学一级，高中一级的数据很少，青年联盟参与者（8-12岁）的数据也很少。这项研究将涉及在青少年足球击中神经认知和成像数据，以确定亚震荡影响的生物力学力量的信息。本研究的所有要素都集中在增加对儿科轻度脑外伤（mTBI）的了解的目标上。在本R 03中，我们将研究儿童mTBI弥散MRI标量测量的生物力学和认知相关性。该项目利用了维克森林大学健康科学的投资，该大学已经确定，装备和招募了青年足球运动员，并资助了数据收集，作为我们正在进行的工作的一部分。 这是一个至关重要的公共领域。我们已经获得了一个非常丰富的数据集，其中包括整个赛季（2012年足球赛季）的30名青年球员（8- 12岁）。所有球员都配备了头部撞击遥测系统（HITS），用于收集所有练习和比赛期间的实时撞击数据。对所有受试者进行基线、季节后和脑震荡后多模态磁共振成像（MRI），包括结构T1加权、扩散张量和峰度成像（DTI/DKI）。在基线、受伤后和赛季后使用小儿脑震荡后即刻评估和认知测试（ImPACT）进行神经认知评估。数据采集现在继续到2013赛季，30名新球员已经接受了HIT的监测，并且都接受了基线成像和神经心理学测试，包括IMPACT测试和额外的NIH工具箱措施。我们最近还获得了内部机构资助，用于获取非接触式运动控制数据集（25名参与者），包括基线和赛季后的成像和认知测试。该R 03将资助一名生物医学工程研究生，以协助对所获得的青少年足球和对照数据进行MRI扩散分析。利用国家的最先进的HIT技术和HIT数据的采集在所有的做法和游戏提供了一个非常彻底的表征所经历的年轻运动员的大脑的生物力学力量。这个独特的数据集代表了世界上最大的同类数据集，结合了青年年龄组的成像，认知测试和生物力学测量。这项研究的长期利益将是允许设备设计师，研究人员和临床医生更好地预防，减轻，识别和治疗伤害，以帮助使足球成为数百万儿童更安全的活动。