iTAKL:Imaging Telemetry And Kinematic modeLing in youth football-High School

iTAKL：青少年足球中的成像遥测和运动学模型-高中

• 批准号: 9981037
• 负责人: Joseph A Maldjian
• 金额: $ 62.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981037
• 关键词: 18 year old; Adolescence; Adolescent; Adverse effects; Affect; Age; Anisotropy; Area; Athletic; Atlases; Attention; Base of the Brain; Behavior assessment; Biomechanics; Biometry; Brain; Brain Concussion; Brain Injuries; Brain imaging; Childhood; Cognitive; Collaborations; Collection; Computer Models; Control Groups; Craniocerebral Trauma; Data; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Elements; Exposure to; Freedom; Functional Magnetic Resonance Imaging; Funding; Growth and Development function; Head; Health Sciences; Image; Incidence; Injury; Investments; Linear Regressions; Magnetic Resonance Imaging; Magnetoencephalography; Manufactured football; Measures; Modeling; Monitor; Motion; Neurocognitive; Neuropsychology; Outcome; Participant; Perfusion; Predisposition; Public Health; Recording of previous events; Regression Analysis; Research Personnel; Rest; Risk; Rotation; Scanning; Seasons; Slow-Wave Sleep; Spin Labels; Sports; Structure; System; Techniques; Telemetry; Time; Translating; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; Youth; base; clinical Diagnosis; clinical epidemiology; cognitive change; cognitive function; cognitive testing; college; data acquisition; data modeling; design; executive function; experience; forest; functional outcomes; gray matter; head impact; high risk; high school; instrument; interest; kinematics; mild traumatic brain injury; multimodality; neuroimaging; neuroinformatics; pediatric traumatic brain injury; prospective; public health relevance; recruit; research clinical testing; response; white matter

 DESCRIPTION (provided by applicant): Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional and collegiate levels, there is less data available for the millions of participants in high school leagues (14-18 years old) during this time of rapid brain development. The purpose of this study is to relate information about cumulative head impact exposure over a season of high school football with neurocognitive and neuroimaging data to determine the effects of sub-concussive impacts on the brain. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI) and prospectively collect biomechanical, imaging, functional, and computational modeling data on a scale never before attempted in adolescents involved in contact sports. This project integrates neuroinformatics work and the computational modeling techniques developed by Drs. Whitlow, Maldjian and Stitzel at Wake Forest University Health Sciences.

 描述（由申请人提供）：足球头部受伤涉及很大的力量，可能导致轻度至重度的脑外伤。虽然这一点越来越受到关注， 在专业和大学一级，在大脑快速发育的这段时期，高中联赛的数百万参与者（14 - 18岁）的数据较少。本研究的目的是将一个赛季的高中橄榄球赛中累积的头部撞击暴露信息与神经认知和神经成像数据相关联，以确定亚震荡撞击对大脑的影响。本研究的所有要素都集中在增加对儿科轻度创伤性脑损伤（mTBI）的理解，并前瞻性地收集生物力学，成像，功能和计算建模数据，这些数据在参与接触性运动的青少年中从未尝试过。该项目整合了神经信息学工作和由维克森林大学健康科学部的Whitlow、Maldjian和Stitzel博士开发的计算建模技术。