iTAKL:Imaging Telemetry And Kinematic modeLing in youth football-High School

iTAKL：青少年足球中的成像遥测和运动学模型-高中

• 批准号: 9981037
• 负责人: Joseph A Maldjian
• 金额: $ 62.33万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9981037
• 关键词: 18 year old; Adolescence; Adolescent; Adverse effects; Affect; Age; Anisotropy; Area; Athletic; Atlases; Attention; Base of the Brain; Behavior assessment; Biomechanics; Biometry; Brain; Brain Concussion; Brain Injuries; Brain imaging; Childhood; Cognitive; Collaborations; Collection; Computer Models; Control Groups; Craniocerebral Trauma; Data; Development; Diffuse; Diffusion Magnetic Resonance Imaging; Elements; Exposure to; Freedom; Functional Magnetic Resonance Imaging; Funding; Growth and Development function; Head; Health Sciences; Image; Incidence; Injury; Investments; Linear Regressions; Magnetic Resonance Imaging; Magnetoencephalography; Manufactured football; Measures; Modeling; Monitor; Motion; Neurocognitive; Neuropsychology; Outcome; Participant; Perfusion; Predisposition; Public Health; Recording of previous events; Regression Analysis; Research Personnel; Rest; Risk; Rotation; Scanning; Seasons; Slow-Wave Sleep; Spin Labels; Sports; Structure; System; Techniques; Telemetry; Time; Translating; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; Youth; base; clinical Diagnosis; clinical epidemiology; cognitive change; cognitive function; cognitive testing; college; data acquisition; data modeling; design; executive function; experience; forest; functional outcomes; gray matter; head impact; high risk; high school; instrument; interest; kinematics; mild traumatic brain injury; multimodality; neuroimaging; neuroinformatics; pediatric traumatic brain injury; prospective; public health relevance; recruit; research clinical testing; response; white matter

 DESCRIPTION (provided by applicant): Football head injuries involve significant forces and can result in mild to severe traumatic brain injuries. While this has received increasing attention at the professional and collegiate levels, there is less data available for the millions of participants in high school leagues (14-18 years old) during this time of rapid brain development. The purpose of this study is to relate information about cumulative head impact exposure over a season of high school football with neurocognitive and neuroimaging data to determine the effects of sub-concussive impacts on the brain. All elements of this study focus on the objective to increase understanding of pediatric mild Traumatic Brain Injury (mTBI) and prospectively collect biomechanical, imaging, functional, and computational modeling data on a scale never before attempted in adolescents involved in contact sports. This project integrates neuroinformatics work and the computational modeling techniques developed by Drs. Whitlow, Maldjian and Stitzel at Wake Forest University Health Sciences.

 描述（由申请人提供）：足球头部损伤涉及很大的力量，可能导致轻度至重度创伤性脑损伤。虽然这已受到越来越多的关注 在职业和大学层面，在这段大脑快速发展的时期，数百万高中联赛参与者（14-18岁）的可用数据较少。本研究的目的是将高中橄榄球赛季中累积的头部撞击暴露信息与神经认知和神经影像数据联系起来，以确定亚震荡撞击对大脑的影响。这项研究的所有内容都集中于提高对儿科轻度创伤性脑损伤 (mTBI) 的了解，并前瞻性地收集生物力学、成像、功能和计算模型数据，其规模是以前从未在参与接触运动的青少年中尝试过的。该项目整合了神经信息学工作和博士开发的计算建模技术。维克森林大学健康科学学院的 Whitlow、Maldjian 和 Stitzel。