System Upgrade for Small-Animal MRI

小动物 MRI 系统升级

• 批准号: 7219798
• 负责人: JOSEPH J. H. ACKERMAN
• 金额: $ 34.07万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7219798
• 关键词: 12 year old; Address; Amplifiers; Animal Model; Animals; Arts; Biomedical Research; Cancer Center; Characteristics; Communities; Comprehensive Cancer Center; Disease; Funding; Grant; Hamsters; Image; Imaging Techniques; Injury; Institution; Invasive; Laboratories; Laboratory Animal Models; Laboratory Animals; Magnetic Resonance; Magnetic Resonance Imaging; Modeling; Molecular Biology; Mus; National Cancer Institute; Optical Tomography; Patients; Positron-Emission Tomography; Power Sources; Protocols documentation; Rattus; Research; Research Infrastructure; Research Personnel; Resources; Site; System; Training; Transgenic Organisms; Translating; Universities; Washington; X-Ray Computed Tomography; in vivo; instrument; instrumentation; interest; magnetic field; method development; optical imaging; programs; tissue fixing

DESCRIPTION (provided by applicant): Small laboratory animal models such as mice, rats and hamsters are widely used throughout the biomedical research community at Washington University and other scientific institutions. With the recent revolution in molecular biology, transgenic laboratory animal models - in particular mice - have become an indispensable part of the biomedical research armamentarium. However, the identification and development of methods for evaluating the characteristics of interest within animal models remains a significant challenge. Nondestructive imaging procedures, such as those offered by magnetic resonance imaging, positron emission tomography, computed tomography, and optical imaging are especially valuable in this regard. The Biomedical Magnetic Resonance Laboratory has responsibility for essentially all small-animal MRI at Washington University. The BMRL is headquarters for the Washington University Small Animal Imaging Resource, which was established specifically to address the need for MRI, PET and, more recently, optical tomography and CT of small laboratory animal models. The National Cancer Institute provides substantial support for WUSAIR through its Small Animal Imaging Research Program. The BMRL is also associated with Washington University's Alvin J. Siteman Cancer Center, an NCI Comprehensive Cancer Center, as headquarters of its Small Animal Imaging Core. This Shared Instrumentation Grant requests funds to upgrade one of the BMRL's core instruments, a 12-year-old, 4.7-tesla, 33-cm small-animal MRI scanner, to state-of-the-art capabilities. This upgrade includes new components from Varian NMR Systems (scanner console), Magnex Scientific (gradient/shim-coil assembly), Copley Controls (gradient amplifier), and Resonance Research (shim power supply) The small- animal MRI scanner being upgraded via this SIG application will be sited, operated, maintained, and administered within the intellectual and administrative infrastructure of the BMRL. The upgraded scanner will provide a platform for a host of studies (and user training) required for support of in vivo and ex vivo (fixed tissue) MRI protocols. Thus, the extensive community of NIH-funded researchers who require access to the BMRL scanners will immediately and directly benefit from the requested magnetic field gradient and console upgrades. RELEVANCE: Small laboratory animal (e.g., mice) disease and injury models are widely used throughout the biomedical research community. Magnetic resonance imaging, the subject of this proposal, allows a safe, non- invasive, non-destructive means to evaluate these models and translate findings to patients.

描述（由申请人提供）：小鼠，大鼠和仓鼠等小型实验室动物模型在华盛顿大学和其他科学机构的生物医学研究界广泛使用。随着分子生物学的最新革命，转基因实验室动物模型（尤其是小鼠）已成为生物医学研究手臂的必不可少的一部分。但是，评估动物模型中感兴趣特征的方法的识别和开发仍然是一个重大挑战。在这方面，磁共振成像，正电子发射断层扫描，计算机层析成像和光学成像提供的非破坏性成像程序在这方面尤其有价值。生物医学磁共振实验室负责华盛顿大学的所有小动物MRI。 BMRL是华盛顿大学小动物成像资源的总部，该资源是专门针对MRI，PET以及最近的光学断层扫描和小型实验室动物模型的CT的需求。国家癌症研究所通过其小型动物成像研究计划为Wusair提供了大量支持。 BMRL还与华盛顿大学的Alvin J. Siteman Cancer Center（NCI综合癌症中心）作为其小动物成像核心的总部有关。这项共享的仪器赠款要求资金升级BMRL的一种核心仪器，即12岁，4.7 Tesla，33厘米小动物MRI扫描仪，以提高最先进的功能。该升级包括来自Varian NMR系统（扫描仪控制台），Magnex Scientific（梯度/垫片组装），Copley Controls（梯度放大器）和共振研究（SHIM电源）的新组件（通过此Sig应用程序升级，在此范围内进行行动和管理范围内，都将通过此Sig进行升级，并进行管理。升级后的扫描仪将为支持体内和Ex Vivo（固定组织）MRI协议所需的大量研究（和用户培训）提供平台。因此，需要使用BMRL扫描仪的NIH资助研究人员的广泛社区将立即并直接从要求的磁场梯度和控制台升级中受益。相关性：小型实验室动物（例如，小鼠）疾病和损伤模型在整个生物医学研究界广泛使用。该提案的主题磁共振成像允许安全，非侵入性，无损的手段评估这些模型并将发现转化为患者。