Genome-wide combined linkage-association scan of multiply phenotyped twin sibships

多表型双胞胎同胞的全基因组组合连锁关联扫描

• 批准号: nhmrc : 389891
• 负责人: Prof Nicholas Martin
• 金额: $ 128.03万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-wide-combined-twin-sibships/96464
• 关键词: Genome; wide; combined; linkage; association

We have a large ongoing study of adolescent twins, their siblings and parents who are multiply phenotyped in many domains including melanoma risk factors, serum biochemistry, and cognition. We used our first Medical Genomics grant to obtain a 5cM linkage scan for>500 families and have identified linkage peaks for many different phenotypes. To fine map these it will be most efficient to carry out a genome-wide association scan. We request funds to type a 500k SNP chip on 1000 individuals.

我们有一个正在进行的大型研究青少年双胞胎，他们的兄弟姐妹和父母谁是多重表型在许多领域，包括黑色素瘤的危险因素，血清生化和认知。我们使用我们的第一个医学基因组学基金获得了500个家庭的5cM连锁扫描，并确定了许多不同表型的连锁峰。为了精细地绘制这些图，进行全基因组关联扫描将是最有效的。我们要求资金在1000人身上输入50万SNP芯片。