Mapping genes for anxiety and depression

绘制焦虑和抑郁基因图谱

• 批准号: nhmrc : 339450
• 负责人: Prof Nicholas Martin
• 金额: $ 50.21万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mapping-genes-anxiety-depression/101314
• 关键词: Mapping; genes; anxiety; depression

High scorers on the personality trait neuroticism are at greatly increased risk of major depression and other neurotic disorders. Neuroticism is a personality trait that shows considerable stability over adulthood. It has a strong genetic basis and it seems that the same genes also determine risk of depression, anxiety and other neuroses. By selecting twins and sibs extremely discordant and concordant (EDAC) for neuroticism we can greatly reduce the cost and increase the power to find genes influencing depression. Questionnaire responses and interviews from 15,027 Australian twins and 11,389 of their family members were reviewed to identify individuals with neuroticism scores in the top and bottom 10%. These individuals were invited to participate in a structured psychiatric interview by telephone, and to give a blood sample. Participation and DNA sampling rates were high and there was minimal evident participation bias. DNA was collected from 2,926 individuals from 884 families including 1,333 EDAC sibling pairs and over 795 parents. A preliminary genome scan on one third of this sample yields several linkage peaks suggesting genes of major effect that appear to replicate findings in similar studies conducted in Holland and England. Given these results it is highly desirable that we obtain a genome scan on the remainder of selected extreme sample. Another one third of this sample is currently being genotyped in America and here we request funds to genotype the remaining third. .If we are successful in identifying genes underlying neuroticism, we will also be able to analyse their contribution to depression and anxiety. This could lead to better drug treatments.

在人格特质神经质上得分高的人患重度抑郁症和其他神经症的风险大大增加。神经质是一种人格特质，在成年后表现出相当的稳定性。它有很强的遗传基础，似乎同样的基因也决定了抑郁、焦虑和其他神经症的风险。通过选择双胞胎和同胞的神经质极端不一致和一致（EDAC），我们可以大大降低成本，增加发现影响抑郁症的基因的能力。研究人员回顾了15，027名澳大利亚双胞胎及其11，389名家庭成员的问卷调查和访谈，以确定神经质得分在前10%和后10%的人。这些人被邀请通过电话参加结构化的精神病学访谈，并提供血液样本。参与率和DNA采样率都很高，参与偏差很小。从884个家庭的2,926个个体中收集了DNA，包括1,333对EDAC兄弟姐妹和超过795对父母。对三分之一样本的初步基因组扫描产生了几个连锁峰，表明主要影响基因似乎复制了在荷兰和英国进行的类似研究中的发现。考虑到这些结果，我们非常希望对所选极端样品的剩余部分进行基因组扫描。另外三分之一的样本目前正在美国进行基因分型，我们在这里要求资金对剩下的三分之一进行基因分型。如果我们成功地识别出神经质的潜在基因，我们也将能够分析它们对抑郁和焦虑的贡献。这可能会导致更好的药物治疗。