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Receptor Specifcity in the Proliferation and Differentiation of Stem Cells

Receptor Specifcity in the Proliferation and Differentiation of Stem Cells
干细胞增殖和分化中的受体特异性
批准号：
7227439
负责人：
C. Anthony Blau
金额：
$31.03万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
项目状态：
已结题
起止时间：
2006-05-01 至 2010-03-31
来源：
https://reporter.nih.gov/project-details/7227439
关键词：
AP20187ActinsAnimal ModelAnimalsB-LymphocytesBinding SitesBiological AssayBloodBlood PlateletsCD34 geneCanis familiarisCell SurvivalCell TherapyCell TransplantsCellsChemicalsChickensComplete Blood CountDimerizationDrug usageElectroporationEmbryoEngineeringErythrocytesErythroid CellsFibroblast Growth Factor 2Fibroblast Growth Factor Receptor 1Flow CytometryFrequenciesGene TransferGenesGoalsGreen Fluorescent ProteinsGrowthGrowth FactorGrowth Factor ReceptorsHematopoiesisHematopoieticHematopoietic stem cellsHumanIn VitroLentivirus VectorLeukocytesLigand BindingMarrowMethodsModelingMonitorMusNatureNumbersOutcomePhenotypePre-Clinical ModelPrincipal InvestigatorProteinsRattusReceptor SignalingRegulationReporterResearch PersonnelSignal TransductionSignaling ProteinSpleenStem cellsSuspension substanceSuspensionsT-LymphocyteTeratomaTestingTherapeuticTimeToxic effectTransgenesTransplantationUndifferentiatedWA01 cell lineantibiotic G 418cell growthcell typecellular engineeringembryonic stem cellgranulocytehuman MPL proteinhuman cord blood CD34+ cellhuman embryonic stem cellhuman embryonic stem cell linehuman stem cellsin vivoprogramspromoterreceptorresponseself-renewalstemtransgene expressionvectorvector control

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英文摘要
DESCRIPTION (provided by applicant): The goal of this application is to test a candidate "universal" cell growth switch, a conditional derivative of the fibroblast growth factor receptor 1, F36VFGFR1, in preclinical models of gene and cell therapy. In specific aim 1, we will test whether different growth factor receptor signaling domains differentially regulate human hemopoiesis. In specific aim 2 we will compare the nature, intensity and duration of the hematopoietic response to F36VFGFR1 signaling versus F36Vmp1 signaling in dogs. In specific aim 3 we will test whether F36VFGFR1 signaling promotes self-renewal in engineered human embryonic stem (ES) cells. We will be using the human embryonic stem cell line WA01.
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Regulation of Embryonic Stem Cell Self-Renewal
  • 批准号：
    8598889
  • 项目类别：
  • 资助金额：
    $35.93万
  • 财政年份：
    2013
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Regulation of Embryonic Stem Cell Self-Renewal
  • 批准号：
    8460654
  • 项目类别：
  • 资助金额：
    $35.5万
  • 财政年份：
    2012
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Modeling Mammalian Genomes
  • 批准号：
    8269673
  • 项目类别：
  • 资助金额：
    $60.61万
  • 财政年份：
    2011
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Modeling Mammalian Genomes
  • 批准号：
    8460150
  • 项目类别：
  • 资助金额：
    $58.7万
  • 财政年份：
    2011
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
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