Receptor Specifcity in the Proliferation and Differentiation of Stem Cells
Receptor Specifcity in the Proliferation and Differentiation of Stem Cells
批准号:
7076455
负责人:
C. Anthony Blau
金额:
$31.88万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-05-01 至 2010-03-31
关键词:
NOD mouseSCID mousebiological signal transductionbiotechnologycell differentiationcell proliferationchemical bindingdogsembryonic stem cellfibroblast growth factorflow cytometrygene therapygenetic manipulationgenetically modified animalsgrowth factor receptorshematopoiesishematopoietic stem cellshematopoietic tissue transplantationhuman embryonic stem cell linehuman tissuelaboratory mouseprotein structure functionreceptor bindingstem cell transplantationtissue /cell culture
中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The goal of this application is to test a candidate "universal" cell growth switch, a conditional derivative of the fibroblast growth factor receptor 1, F36VFGFR1, in preclinical models of gene and cell therapy. In specific aim 1, we will test whether different growth factor receptor signaling domains differentially regulate human hemopoiesis. In specific aim 2 we will compare the nature, intensity and duration of the hematopoietic response to F36VFGFR1 signaling versus F36Vmp1 signaling in dogs. In specific aim 3 we will test whether F36VFGFR1 signaling promotes self-renewal in engineered human embryonic stem (ES) cells. We will be using the human embryonic stem cell line WA01.
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专著(0)
科研奖励(0)
会议论文
Regulation of Embryonic Stem Cell Self-Renewal
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批准号:8598889
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项目类别:
-
资助金额:$35.93万
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财政年份:2013
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负责人:C. Anthony Blau
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依托单位:
Regulation of Embryonic Stem Cell Self-Renewal
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批准号:8460654
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项目类别:
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资助金额:$35.5万
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财政年份:2012
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负责人:C. Anthony Blau
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依托单位:
Modeling Mammalian Genomes
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批准号:8269673
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项目类别:
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资助金额:$60.61万
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财政年份:2011
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负责人:C. Anthony Blau
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依托单位:
Modeling Mammalian Genomes
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批准号:8460150
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项目类别:
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资助金额:$58.7万
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财政年份:2011
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负责人:C. Anthony Blau
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依托单位:
Modeling Mammalian Genomes
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批准号:8135058
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项目类别:
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资助金额:$60.88万
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财政年份:2011
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负责人:C. Anthony Blau
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依托单位:
Cell Biosystems Firefly 3000 system
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批准号:7792826
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项目类别:
-
资助金额:$31.84万
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财政年份:2010
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:7928595
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项目类别:
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资助金额:$94.04万
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财政年份:2009
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负责人:C. Anthony Blau
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依托单位:
Erythropoietin Blockade for the Treatment of Cancer
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批准号:8125048
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项目类别:
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资助金额:$40.14万
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财政年份:2008
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负责人:C. Anthony Blau
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依托单位:
Erythropoietin Blockade for the Treatment of Cancer
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批准号:8300194
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项目类别:
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资助金额:$40.26万
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财政年份:2008
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负责人:C. Anthony Blau
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依托单位:
Erythropoietin Blockade for the Treatment of Cancer
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批准号:7692926
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项目类别:
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资助金额:$40.83万
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财政年份:2008
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:7475086
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项目类别:
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资助金额:$195.56万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:7303498
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项目类别:
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资助金额:$192.83万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Administrative Core
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批准号:7356492
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项目类别:
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资助金额:$12.52万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:8119430
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项目类别:
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资助金额:$192.73万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:7903429
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项目类别:
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资助金额:$194.68万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Regulation of Human Embryonic Stem Cell Self-Renewal
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批准号:7356487
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项目类别:
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资助金额:$33.88万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Embryonic Stem Cells
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批准号:7664942
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项目类别:
-
资助金额:$195.65万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Human Embryonic Stem Cells
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批准号:8598888
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项目类别:
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资助金额:$197.0万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Self Renewal and Differentiation of Human Embryonic Stem Cells
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批准号:8414915
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项目类别:
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资助金额:$198.19万
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财政年份:2007
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负责人:C. Anthony Blau
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依托单位:
Receptor Specifcity in the Proliferation and Differentiation of Stem Cells
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批准号:7227439
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项目类别:
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资助金额:$31.03万
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财政年份:2006
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负责人:C. Anthony Blau
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依托单位:
海外基金