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Modeling Mammalian Genomes

Modeling Mammalian Genomes
哺乳动物基因组建模
批准号：
8135058
负责人：
C. Anthony Blau
金额：
$60.88万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
项目状态：
已结题
起止时间：
2011-05-30 至 2014-04-30
来源：
https://reporter.nih.gov/project-details/8135058
关键词：
AdoptedAllelesArchitectureCCCTC-binding factorCellsCellular biologyCentromereChromatinChromosomesCodeComplexDNA replication originDataData SetDevelopmentDiploidyEP300 geneEnhancersEpigenetic ProcessFrequenciesFunctional RNAFungal GenomeGenesGenetic TranscriptionGenomeGenomicsGenotypeHaploidyHybrid CellsHybridsHypoxanthine PhosphoribosyltransferaseKidneyLightMapsMethodsModelingMolecular ConformationMusNaturePhenotypeProtein BindingRNAResearch PersonnelRodentRoleSaccharomyces cerevisiaeScaffolding ProteinSingle Nucleotide PolymorphismStructureStructure-Activity RelationshipSurveysTechniquesTechnologyTransfer RNAUnited States National Institutes of HealthX Chromosomebasecell typecohesingenetic elementgenome-widehistone modificationmammalian genomepromoterspatial relationshiptelomerethree-dimensional modeling

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DESCRIPTION (provided by applicant): Recently, genomes have been recognized to adopt preferred physical architectures that are evolutionarily conserved and cell type specific. We developed a method for characterizing long-range inter- and intra- chromosomal interactions on a genome-wide scale. Our method is based on chromatin conformation capture (3C) but unlike 3C (or other derivative technologies), makes no a priori assumptions regarding interacting genetic elements. Due to the large size of mammalian genomes we initially validated our approach in haploid Saccharomyces cerevisiae. In this application we propose to use this method to understand the relationship between genome architecture and allele specific expression in mammalian development.
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Regulation of Embryonic Stem Cell Self-Renewal
  • 批准号：
    8598889
  • 项目类别：
  • 资助金额：
    $35.93万
  • 财政年份：
    2013
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Regulation of Embryonic Stem Cell Self-Renewal
  • 批准号：
    8460654
  • 项目类别：
  • 资助金额：
    $35.5万
  • 财政年份：
    2012
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Modeling Mammalian Genomes
  • 批准号：
    8269673
  • 项目类别：
  • 资助金额：
    $60.61万
  • 财政年份：
    2011
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
Modeling Mammalian Genomes
  • 批准号：
    8460150
  • 项目类别：
  • 资助金额：
    $58.7万
  • 财政年份：
    2011
  • 负责人：
    C. Anthony Blau
  • 依托单位：
    UNIVERSITY OF WASHINGTON
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