Novel Tools and Principles for Precisely Controlling Brain Activity

精确控制大脑活动的新工具和原理

• 批准号: 7430134
• 负责人: Edward S. Boyden
• 金额: $ 251.75万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7430134
• 关键词: 3-Dimensional; A Mouse; Ablation; Action Potentials; Address; Adverse effects; Affect; Age; Algorithms; Americas; Animal Model; Anxiety; Apomorphine; Area; Arts; Attention; Auras; Autoimmune Process; Award; Back; Basic Science; Behavior; Behavior assessment; Behavioral; Behavioral Assay; Behavioral Model; Biochemistry; Biological; Biological Assay; Biological Response Modifier Therapy; Biology; Biomedical Engineering; Biophysics; Biotechnology; Body Surface; Brain; Brain Diseases; Brain Injuries; Brain Neoplasms; Brain region; Brodmann' s area; Cardiac; Cations; Cells; Cerebellum; Cerebral cortex; Chemicals; Child; Chloride Ion; Chlorides; Chromosome Pairing; Chronic; Class; Classification; Cleaved cell; Clinical; Clinical Engineering; Clinical Research; Codon Nucleotides; Cognition; Cognitive; Collaborations; Communities; Complex; Complication; Computers; Condition; Conscious; Corpus striatum structure; Cosmetics; Coupled; Creativeness; Custom; Cutaneous; Darkness; Data; Deep Brain Stimulation; Depth; Development; Devices; Diagnosis; Dimensions; Discipline; Disease; Disease model; Doctor of Philosophy; Dreams; Economics; Educational process of instructing; Electric Stimulation; Electrical Engineering; Electrocardiogram; Electrodes; Electroencephalography; Electromagnetics; Elements; Engineering; England; Environmental Wind; Epilepsy; Equipment; Esthesia; European; Event; Expert Opinion; Failure; Feeling; Fiber; Figs - dietary; Fire - disasters; Focused Ultrasound Therapy; Foundations; Freezing; Frequencies; Functional Magnetic Resonance Imaging; Funding Mechanisms; Future; Gambling; Gene Expression; Generations; Genomics; Glues; Goals; Halorhodopsins; Hand; Happiness; Head; Headache; Health; Health Care Costs; Health system; Healthcare; Heart; Heating; Hemorrhage; Heterogeneity; Hippocampus (Brain); Human; Human Experimentation; Image; Implant; Indium; Individual; Industry; Infection; Injection of therapeutic agent; Institutes; Intelligence; International; Internist; Intervention; Invasive; Investments; Ion Channel; Japan; Joints; Journals; Knowledge; Laboratories; Lasers; Laws; Lead; Leadership; Learning; Left; Legal patent; Length; Life; Light; Link; Location; Love; Machine Learning; Magnetic Resonance Imaging; Magnetism; Maps; Marketing; Marshal; Measurable; Measurement; Measures; Medial; Mediating; Medical; Medicine; Memory; Mental Depression; Mental Health; Mental disorders; Methods; Migraine; Mind; Mission; Modality; Modeling; Molecular; Motor; Mus; Names; National Institute of Drug Abuse; National Institute of Mental Health; Nature; Navigation System; Nerve; Nerve Degeneration; Nerve Tissue; Neurobiology; Neurologic; Neurological Models; Neurologist; Neurology; Neurons; Neurorehabilitation; Neurosciences; Neurosurgeon; New England; New Territories; Numbers; Obesity; Occupations; Oceans; Operative Surgical Procedures; Optic Nerve; Optics; Other Agency or Organization; Outcome; Pain; Paper; Parkinson Disease; Parvalbumins; Pathology; Patients; Pattern; Penetration; Peptides; Phase; Phenotype; Philosophy; Physics; Physiologic pulse; Physiological; Physiology; Play; Polishes; Population; Positioning Attribute; Postdoctoral Fellow; Preventive Medicine; Primates; Prize; Procedures; Process; Property; Proteins; Psyche structure; Psychiatrist; Psychiatry; Public Health; Publishing; Pulse taking; Pump; Radiation; Radiology Specialty; Rana; Range; Rate; Rattus; Reagent; Recording of previous events; Relative (related person); Reporting; Research; Research Personnel; Resolution; Rest; Rewards; Risk; Robotics; Rodent; Role; Rotation; Running; Safety; San Francisco; Schizophrenia; Scholarship; Schools; Science; Scientist; Score; Screening procedure; Seizures; Shapes; Side; Signal Transduction; Site; Slice; Societies; Software Design; Solutions; Somatostatin; Specific qualifier value; Standards of Weights and Measures; Stimulus; Structure; Students; Surgeon; Surgical sutures; Surveys; Switzerland; Symptoms; Synapses; System; Talents; Techniques; Technology; Testing; Tetracycline; Tetracyclines; Therapeutic; Therapeutic Intervention; Thick; Thinking; Time; Tissues; Touch sensation; Toy; Training; Transcranial magnetic stimulation; Translations; Travel; Trigeminal Nuclei; Ultrasonics; Ultrasonography; United States National Academy of Sciences; United States National Institutes of Health; Universities; Ursidae Family; Visual Cortex; Washington; Week; Work; World Health Organization; Writing; absorption; abstracting; addiction; analog; animation; awake; base; biobehavior; brain research; brain tissue; calmodulin-dependent protein kinase II; career; cell type; ceric oxide; chronic pain; cingulate cortex; clinical application; clinical efficacy; combinatorial; computer science; cost; cranium; deep brain stimulator; design; desire; electric field; electromagnetism; experience; falls; forgetting; health organization; high throughput screening; implantation; improved; in vivo; innovation; insight; interest; magnetic field; man; member; millimeter; millisecond; mind control; miniaturize; mouse model; nervous system disorder; neural circuit; neural stimulation; neuroimaging; neurophysiology; neuroregulation; neurosurgery; neurotechnology; new technology; next generation; novel; novel strategies; optical fiber; optical imaging; optimism; pressure; professor; programs; promoter; prototype; quantum; rapid technique; receptor; relating to nervous system; repaired; research study; scale up; sciatic nerve; size; skills; sound; statistics; success; tool; transmission process; trend; ultraviolet; vector; virology

The finding that many neurological and psychiatric disorders are associated with abnormal neural activity in specific brain circuits raises the optimism that a precise, flexible technology for controlling neural activity would enable the systematic treatment of many brain disorders. I here propose to take a top-down approach to developing a new tool for noninvasive, focal, deep-targetable control of brain circuits. I also propose to discover informed principles governing the use of these tools to control activity in a diversity of neural circuits relevant for different illnesses. Through far-reaching collaborations, I will not only invent these tools and discover how to use them, but lead their translation into clinical application. I believe that this is the right time and place to tackle this intellectual challenge, given my unique training, as well as my proven abilities to synthesize new insights from disparate fields, and to lead interdisciplinary teams into new territory.

许多神经和精神疾病与神经活动异常有关， 特定的大脑回路使人们乐观地认为，一种精确、灵活的控制神经活动的技术， 能够系统地治疗许多脑部疾病。我在这里建议采取自上而下的方法， 开发一种新的工具，用于非侵入性的、局部的、可深层靶向控制大脑回路。我亦建议 发现使用这些工具控制各种神经回路活动的知情原则 与不同的疾病有关。通过广泛的合作，我不仅会发明这些工具， 发现如何使用它们，并将其转化为临床应用。我相信现在是时候 和地方来解决这个智力挑战，鉴于我独特的训练，以及我的能力， 综合不同领域的新见解，并带领跨学科团队进入新的领域。

项目成果

Face-selective electrostatic control of hydrothermal zinc oxide nanowire synthesis.

• DOI: 10.1038/nmat3069
• 发表时间: 2011-07-10
• 期刊: Nature materials
• 影响因子: 41.2

Automated whole-cell patch-clamp electrophysiology of neurons in vivo.

• DOI: 10.1038/nmeth.1993
• 发表时间: 2012-06
• 期刊: NATURE METHODS
• 影响因子: 48
• 作者: Kodandaramaiah, Suhasa B.;Franzesi, Giovanni Talei;Chow, Brian Y.;Boyden, Edward S.;Forest, Craig R.
• 通讯作者: Forest, Craig R.

Mechanistic insights into radical formation and functionalization in copper/N-fluorobenzenesulfonimide radical-relay reactions.

对铜/N-氟苯甲酰亚胺自由基反应反应的自由基形成和功能化的机械洞察力。

• DOI: 10.1039/d3sc03597b
• 发表时间: 2024-01-24
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Mandal, Mukunda;Buss, Joshua A.;Chen, Si-Jie;Cramer, Christopher J.;Stahl, Shannon S.
• 通讯作者: Stahl, Shannon S.

Toward the second generation of optogenetic tools.

• DOI: 10.1523/jneurosci.4190-10.2010
• 发表时间: 2010-11-10
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Knöpfel T;Lin MZ;Levskaya A;Tian L;Lin JY;Boyden ES
• 通讯作者: Boyden ES

Processes for design, construction and utilisation of arrays of light-emitting diodes and light-emitting diode-coupled optical fibres for multi-site brain light delivery.

用于多部位脑光传输的发光二极管阵列和发光二极管耦合光纤的设计、构造和利用过程。

• DOI: 10.1049/joe.2014.0304
• 发表时间: 2015
• 期刊: Journal of engineering (Stevenage, England)
• 作者: Bernstein,JacobG;Allen,BrianD;Guerra,AlexanderA;Boyden,EdwardS
• 通讯作者: Boyden,EdwardS