精确控制大脑活动的新工具和原理-猫眼课题宝

精确控制大脑活动的新工具和原理

批准号：

7430134

负责人：

Edward S. Boyden

金额：

$251.75万

依托单位：

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

依托单位国家：

美国

项目类别：

财政年份：

2007

资助国家：

美国

项目状态：

已结题

起止时间：

2007-09-30 至 2012-08-31

来源：

https://reporter.nih.gov/project-details/7430134

关键词：

3-Dimensional A Mouse Ablation Action Potentials Address Adverse effects Affect Age Algorithms Americas Animal Model Anxiety Apomorphine Area Arts Attention Auras Autoimmune Process Award Back Basic Science Behavior Behavior assessment Behavioral Behavioral Assay Behavioral Model Biochemistry Biological Biological Assay Biological Response Modifier Therapy Biology Biomedical Engineering Biophysics Biotechnology Body Surface Brain Brain Diseases Brain Injuries Brain Neoplasms Brain region Brodmann&apos s area Cardiac Cations Cells Cerebellum Cerebral cortex Chemicals Child Chloride Ion Chlorides Chromosome Pairing Chronic Class Classification Cleaved cell Clinical Clinical Engineering Clinical Research Codon Nucleotides Cognition Cognitive Collaborations Communities Complex Complication Computers Condition Conscious Corpus striatum structure Cosmetics Coupled Creativeness Custom Cutaneous Darkness Data Deep Brain Stimulation Depth Development Devices Diagnosis Dimensions Discipline Disease Disease model Doctor of Philosophy Dreams Economics Educational process of instructing Electric Stimulation Electrical Engineering Electrocardiogram Electrodes Electroencephalography Electromagnetics Elements Engineering England Environmental Wind Epilepsy Equipment Esthesia European Event Expert Opinion Failure Feeling Fiber Figs - dietary Fire - disasters Focused Ultrasound Therapy Foundations Freezing Frequencies Functional Magnetic Resonance Imaging Funding Mechanisms Future Gambling Gene Expression Generations Genomics Glues Goals Halorhodopsins Hand Happiness Head Headache Health Health Care Costs Health system Healthcare Heart Heating Hemorrhage Heterogeneity Hippocampus (Brain)Human Human Experimentation Image Implant Indium Individual Industry Infection Injection of therapeutic agent Institutes Intelligence International Internist Intervention Invasive Investments Ion Channel Japan Joints Journals Knowledge Laboratories Lasers Laws Lead Leadership Learning Left Legal patent Length Life Light Link Location Love Machine Learning Magnetic Resonance Imaging Magnetism Maps Marketing Marshal Measurable Measurement Measures Medial Mediating Medical Medicine Memory Mental Depression Mental Health Mental disorders Methods Migraine Mind Mission Modality Modeling Molecular Motor Mus Names National Institute of Drug Abuse National Institute of Mental Health Nature Navigation System Nerve Nerve Degeneration Nerve Tissue Neurobiology Neurologic Neurological Models Neurologist Neurology Neurons Neurorehabilitation Neurosciences Neurosurgeon New England New Territories Numbers Obesity Occupations Oceans Operative Surgical Procedures Optic Nerve Optics Other Agency or Organization Outcome Pain Paper Parkinson Disease Parvalbumins Pathology Patients Pattern Penetration Peptides Phase Phenotype Philosophy Physics Physiologic pulse Physiological Physiology Play Polishes Population Positioning Attribute Postdoctoral Fellow Preventive Medicine Primates Prize Procedures Process Property Proteins Psyche structure Psychiatrist Psychiatry Public Health Publishing Pulse taking Pump Radiation Radiology Specialty Rana Range Rate Rattus Reagent Recording of previous events Relative (related person)Reporting Research Research Personnel Resolution Rest Rewards Risk Robotics Rodent Role Rotation Running Safety San Francisco Schizophrenia Scholarship Schools Science Scientist Score Screening procedure Seizures Shapes Side Signal Transduction Site Slice Societies Software Design Solutions Somatostatin Specific qualifier value Standards of Weights and Measures Stimulus Structure Students Surgeon Surgical sutures Surveys Switzerland Symptoms Synapses System Talents Techniques Technology Testing Tetracycline Tetracyclines Therapeutic Therapeutic Intervention Thick Thinking Time Tissues Touch sensation Toy Training Transcranial magnetic stimulation Translations Travel Trigeminal Nuclei Ultrasonics Ultrasonography United States National Academy of Sciences United States National Institutes of Health Universities Ursidae Family Visual Cortex Washington Week Work World Health Organization Writing absorption abstracting addiction analog animation awake base biobehavior brain research brain tissue calmodulin-dependent protein kinase II career cell type ceric oxide chronic pain cingulate cortex clinical application clinical efficacy combinatorial computer science cost cranium deep brain stimulator design desire electric field electromagnetism experience falls forgetting health organization high throughput screening implantation improved in vivo innovation insight interest magnetic field man member millimeter millisecond mind control miniaturize mouse model nervous system disorder neural circuit neural stimulation neuroimaging neurophysiology neuroregulation neurosurgery neurotechnology new technology next generation novel novel strategies optical fiber optical imaging optimism pressure professor programs promoter prototype quantum rapid technique receptor relating to nervous system repaired research study scale up sciatic nerve size skills sound statistics success tool transmission process trend ultraviolet vector virology

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英文摘要

The finding that many neurological and psychiatric disorders are associated with abnormal neural activity in specific brain circuits raises the optimism that a precise, flexible technology for controlling neural activity would enable the systematic treatment of many brain disorders. I here propose to take a top-down approach to developing a new tool for noninvasive, focal, deep-targetable control of brain circuits. I also propose to discover informed principles governing the use of these tools to control activity in a diversity of neural circuits relevant for different illnesses. Through far-reaching collaborations, I will not only invent these tools and discover how to use them, but lead their translation into clinical application. I believe that this is the right time and place to tackle this intellectual challenge, given my unique training, as well as my proven abilities to synthesize new insights from disparate fields, and to lead interdisciplinary teams into new territory.

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