Fibroid Growth Study

肌瘤生长研究

• 批准号: 7330675
• 负责人: SHYAMAL PEDDADA
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7330675
• 关键词: Fibroid; Growth; Study

Uterine leiomyomas, commonly called fibroids, are a major health concern for women of reproductive age. The objectives of the study described herein are to investigate the growth dynamics of uterine leiomyomas in a clinically relevant population of women. Basic questionsof interest in this project are test the hypotheses that uterine leiomyomas are heterogeneous in terms of their growth characteristics and in their clinical symptoms or outcomes, and that differences in leiomyoma growth dynamics can be discriminated by molecular markers and cellular phenotypes. Study included about 115 premenopausal women (>18 years old) with at least one uterine leiomyoma. The inclusion criteria for patient enrollment is confirmed diagnosis of leiomyoma by ultrasound. At least one leiomyoma must be equal to or greater than 2 cm in diameter or the uterus must be enlarged to the size typical during the eighth week of pregnancy (indicating many leiomyomas are present). After enrollment and informed consent, T1- and T2-weighted magnetic resonance image (MRI) scans were conducted beginning at the first visit and then at 3, 6, and 12 months. Each patient had a physical exam and provided urine and blood samples at each MRI visit, and responded to an initial extensive telephone-administered questionnaire followed by abbreviated monthly questionnaire updates. Of these, 28 women required surgical intervention (hysterectomy/ myomectomy). Leiomyoma samples from these women were analyzed for histopathological and molecular changes correlated with growth. The specific aims of the study are to: (1) investigate leiomyoma growth as a function of multiplicity and location; (2) examine the relationship between leiomyoma growth and clinical symptoms or outcome; (3) identify molecular, cellular, and pathological characteristics of leiomyomas with differing growth dynamics; and (4) examine endocrinological parameters and lifestyle factors related to differential growth dynamics of uterine leiomyomas.

子宫平滑肌瘤，通常称为纤维瘤，是育龄妇女的主要健康问题。本文所述研究的目的是调查临床相关女性人群中子宫平滑肌瘤的生长动力学。本项目的基本问题是检验子宫平滑肌瘤在其生长特征和临床症状或结果方面具有异质性的假设，以及平滑肌瘤生长动力学的差异可以通过分子标记和细胞表型来区分。研究包括约115名绝经前妇女（>18岁），至少有一个子宫平滑肌瘤。患者入组的入选标准为超声确诊平滑肌瘤。至少有一个平滑肌瘤必须等于或大于2厘米的直径或子宫必须扩大到典型的大小在怀孕的第八周（表明许多平滑肌瘤存在）。入组和知情同意后，从首次访视开始，然后在3、6和12个月时进行T1和T2加权磁共振成像（MRI）扫描。每位患者在每次MRI访视时进行体格检查并提供尿液和血液样本，并回答最初的广泛电话问卷，然后每月更新简短的问卷。其中，28名妇女需要手术干预（子宫切除术/肌瘤切除术）。对这些妇女的平滑肌瘤样本进行组织病理学和与生长相关的分子变化分析。本研究的具体目的是：（1）研究平滑肌瘤生长作为多样性和位置的函数;（2）检查平滑肌瘤生长与临床症状或结果之间的关系;（3）识别具有不同生长动力学的平滑肌瘤的分子、细胞和病理学特征;和（4）检查与子宫肌瘤差异生长动力学相关的内分泌参数和生活方式因素。