NIEHS Statistical Consulting Service

NIEHS统计咨询服务

• 批准号: 8336549
• 负责人: SHYAMAL PEDDADA
• 金额: $ 84.23万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8336549
• 关键词: Agreement; Biometry; Candidate Disease Gene; Characteristics; Cleft Lip; Cleft Palate; Collaborations; Congenital Abnormality; Consult; Data; Data Analyses; Data Reporting; Denmark; Embryo; Epidemiologic Studies; Exposure to; Genes; Genetic; Genotype; Growth; Habits; Hormonal; Hormones; Human; Human Chorionic Gonadotropin; Immune response; Inherited; Joints; Journals; Laboratories; Length; Luteal Phase; Manuscripts; Measurement; Mediating; Menstrual cycle; National Institute of Environmental Health Sciences; Norway; Occupational Asthma; Oral; Ovulation; Paper; Parents; Pattern; Phenotype; Physicians; Pituitary Gland; Population; Pregnancy; Pregnancy loss; Preparation; Process; Publications; Publishing; Reporting; Research; Research Personnel; Risk; Scientist; Services; Single Nucleotide Polymorphism; Smoker; Smoking; Spontaneous abortion; Staging; Surveys; Triad Acrylic Resin; United States National Institutes of Health; Universities; Urine; base; clinical effect; design; family genetics; implantation; maternal cigarette smoking; older women; prenatal exposure

The biostatisticians participating in the statistical consulting service co-authored several research publications in collaboration with scientists within DIR and outisde the DIR. Manuscripts that were published during this year are listed below and there are several more that are either in preparation or in various stages of the review process. Some examples of our collaborative research are as follows: 1. Jukic et al. (2010,2011) analyzed data from the Early Pregnancy Study. Effects of clinical spontaneous abortion on pituitary function in the subsequent menstrual cycle have been reported, but data are sparse on unrecognized very early loss. In these papers, the authors used daily urine-based hormonal measurements based on the Early Pregnancy Study to compare hormonal patterns and menstrual-cycle characteristics (such as luteal phase length) in cycles following early pregnancy loss. Any effects of early loss on the subsequent cycle are evidently small. In a second set of analyses the authors explored possible determinants of late implantation and slow initial risk of hCG in naturally-conceived pregnancies. Older women tended to have a longer interval from ovulation to implantation, as did smokers. A later implantation has previously been shown to be associated with early pregnancy loss. Excluding the early losses the authors explored factors in relation to the rate of rise of the pregnancy hormone, hCG, with the idea that this rise can serve as a marker for the early growth of the embryo. A number of factors, including maternal smoking and maternal prenatal exposure to DES, were associated with the pattern of increase of hCG. 2. Jugessur et al. (2010,2011) carried out genetic family-based analyses of cases of the birth defect oral clefting based on 357 candidate genes represented by 1536 SNPs for 562 case-parent triads in Norway and 236 triads in Denmark. For maternally-mediated genetic effects the gene FNLB was implicated in both populations for the cleft-palate-only phenotype. Strong and consistent effects were not seen for the other genes. In analyses of effects of the fetally inherited markers, the gene FGF12 was implicated in both populations for the cleft-lip-only phenotype. There was some evidence for IRF6, which had been previously reported as associated with clefting. 3. The NTP has a collaborative agreement with NIOSH and the University of Cincinnati to study the effects of diisocyanate compounds on occupational asthma. In this study, workers with and without occupational asthma have been surveyed, examined by physicians, and genotyped for selected single nucleotide polymorphisms (SNPs) in genes related to immune responses. Bernstein et al. (2011)analyzed the associations between these SNPs and occupational asthma, along with additional information such as smoking habits and exposure intensity and duration.

参与统计咨询服务的生物统计学家与联合国内外的科学家合作，共同撰写了几份研究出版物。下文列出了今年发表的宣言，还有一些宣言正在编写或处于审查进程的不同阶段。 我们合作研究的一些例子如下： 1. Jukic等人（2010，2011）分析了早期妊娠研究的数据。 临床自然流产对随后月经周期垂体功能的影响已有报道，但未被认识到的极早期损失的数据很少。 在这些论文中，作者使用基于早孕研究的每日尿液激素测量来比较早孕丢失后周期中的激素模式和月经周期特征（如黄体期长度）。 早期损失对后续周期的任何影响显然很小。 在第二组分析中，作者探讨了自然妊娠中延迟着床和hCG初始风险缓慢的可能决定因素。 年龄较大的妇女从排卵到着床的间隔往往较长，吸烟者也是如此。 先前已经证明，晚期植入与早期妊娠丢失有关。 排除早期损失，作者探讨了与妊娠激素hCG上升速率相关的因素，认为这种上升可以作为胚胎早期生长的标志。 许多因素，包括母亲吸烟和母亲产前暴露于DES，与hCG增加的模式。 2. Jugessur et al.（2010，2011）对出生缺陷口腔裂病例进行了基于遗传家族的分析，基于挪威562个病例-父母三联体和丹麦236个三联体的357个候选基因（由1536个SNP代表）。 对于母体介导的遗传效应，基因FNLB在两个群体中均涉及腭裂仅表型。对于其他基因没有观察到强烈和一致的影响。 在胎儿遗传标记的影响的分析中，基因FGF 12在两个群体中都涉及唇裂表型。 有一些IRF 6的证据，以前曾报道与分裂有关。 3. NTP与NIOSH和辛辛那提大学签订了合作协议，研究二异氰酸酯化合物对职业性哮喘的影响。 在这项研究中，有和没有职业性哮喘的工人进行了调查，由医生检查，并在免疫反应相关基因中选择单核苷酸多态性（SNP）进行基因分型。 伯恩斯坦et al.（2011）分析了这些SNP与职业性哮喘之间的关联，沿着其他信息，如吸烟习惯、暴露强度和持续时间。

项目成果

Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.

丁丙诺啡、美洛昔康和氟尼辛葡甲胺对小鼠术后镇痛的作用。

• 发表时间: 2011
• 期刊: Journal of the American Association for Laboratory Animal Science : JAALAS
• 作者: Tubbs,JacquelynT;Kissling,GraceE;Travlos,GregS;Goulding,DavidR;Clark,JamesA;King-Herbert,AngelaP;Blankenship-Paris,TerryL
• 通讯作者: Blankenship-Paris,TerryL

Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

• DOI: 10.1158/1541-7786.mcr-10-0496
• 发表时间: 2011-03
• 期刊: Molecular cancer research : MCR
• 作者: Monti P;Perfumo C;Bisio A;Ciribilli Y;Menichini P;Russo D;Umbach DM;Resnick MA;Inga A;Fronza G
• 通讯作者: Fronza G

Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε.

• DOI: 10.1016/j.dnarep.2011.02.001
• 发表时间: 2011-05-05
• 期刊: DNA repair
• 影响因子: 3.8
• 作者: Clark AB;Lujan SA;Kissling GE;Kunkel TA
• 通讯作者: Kunkel TA

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.

• DOI: 10.1158/0008-5472.can-08-4455
• 发表时间: 2009-06
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Eva M Schindler;A. Hindes;Erin L Gribben;Carole J. Burns;Yan Yin;Meei-Hua Lin;Robert J. Owen;G. Longmore;G. Kissling;J. Arthur;T. Efimova

Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays.

国家毒理学计划两年生物测定中化学致癌作用的性别差异。

• DOI: 10.1177/0192623312446527
• 发表时间: 2012
• 期刊: Toxicologic pathology
• 影响因子: 1.5
• 作者: Kadekar,Sandeep;Peddada,Shyamal;Silins,Ilona;French,JohnE;Högberg,Johan;Stenius,Ulla
• 通讯作者: Stenius,Ulla