Collaborative research in environmental health sciences

环境健康科学合作研究

• 批准号: 8929817
• 负责人: SHYAMAL PEDDADA
• 金额: $ 9.77万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8929817
• 关键词: Asthma; Chemicals; Collaborations; DNA Methylation; Data; Data Analyses; Disease; Environment; Environmental Health; Epidemiologic Studies; Extramural Activities; Goals; Health; Human; Infant; Institutes; Joints; Journals; Laboratories; London; Manuscripts; Mental Depression; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Obesity; Outcome; Play; Pregnancy; Public Health; Publications; Research; Research Personnel; Role; Smoke; Staging; Statistical Methods; Umbilical Cord Blood; design; early childhood; interest; maternal cigarette smoking; microbial; microbiome; novel

Several collaborations have been carried out in this project with intramural as well as extramural researchers during the FY 2012-2013 on a wide range of topics. These collaborations have led to several manuscripts that are currently at various stages of publication. Some examples of collaborations are as follows. 1. Study of infant gut microbiome: In addition to the external (chemical) environment, the internal (microbial) environment plays an important role in human health. In recent years there has been considerable interest among researchers to understand the effect of microbiome on various health conditions and diseases, such as obesity, asthma, IBD, depression etc. In collaboration with researchers at the Norwegian Institute of Public Health, in this project we are trying to understand the associations between infant gut microbiome and some early childhood health outcomes. Novel statistical methods are being developed for drawing such associations. 2. Study of DNA methylation in newborns of mothers who smoked during their pregnancy: Maternal smoking during pregnancy is known to be associated with a variety health outcomes in babies. In collaboration with Dr. Stephanie London (EB), we are investigating the effect of maternal smoking during pregnancy on DNA methylation in cord blood obtained from newborns.

在2012-2013财政年度期间，在该项目中与校内和校外研究人员就广泛的主题开展了几次合作。 这些合作产生了几份手稿，目前正处于不同的出版阶段。合作的一些例子如下。 1.婴儿肠道微生物组的研究：除了外部（化学）环境外，内部（微生物）环境对人类健康起着重要作用。近年来，研究人员对了解微生物组对各种健康状况和疾病（例如肥胖、哮喘、炎症性肠病、抑郁症等）的影响产生了浓厚的兴趣。与挪威公共卫生研究所的研究人员合作，在该项目中，我们试图了解婴儿肠道微生物组与一些幼儿健康结果之间的关联。正在开发新的统计方法来绘制这种关联。 2.在怀孕期间吸烟的母亲的新生儿中的DNA甲基化研究：已知怀孕期间的母亲吸烟与婴儿的各种健康结果有关。我们与Stephanie伦敦博士（EB）合作，正在研究母亲在怀孕期间吸烟对新生儿脐带血DNA甲基化的影响。