Collaborative research in environmental health sciences

环境健康科学合作研究

• 批准号: 8734177
• 负责人: SHYAMAL PEDDADA
• 金额: $ 10.84万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8734177
• 关键词: Asthma; CYP1A1 gene; Chemicals; Collaborations; DNA Methylation; Data; Data Analyses; Disease; Environment; Environmental Health; Epidemiologic Studies; Epigenetic Process; Exposure to; Extramural Activities; Genes; Goals; Health; Human; Infant; Institutes; Investigation; Joints; Journals; Laboratories; London; Manuscripts; Maps; Mental Depression; Methods; Modification; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Obesity; Outcome; Perinatal Exposure; Play; Pregnancy; Public Health; Publications; RUNX1 gene; Research; Research Personnel; Role; Site; Smoke; Smoking; Staging; Statistical Methods; Tobacco smoke; Umbilical Cord Blood; design; early childhood; genome-wide; interest; maternal cigarette smoking; microbial; microbiome; novel

Several collaborations have been carried out in this project with intramural as well as extramural researchers during the FY 2012-2013 on a wide range of topics. These collaborations have led to several manuscripts that are currently at various stages of publication. Some examples of collaborations are as follows. 1. Study of infant gut microbiome: In addition to the external (chemical) environment, the internal (microbial) environment plays an important role in human health. In recent years there has been considerable interest among researchers to understand the effect of microbiome on various health conditions and diseases, such as obesity, asthma, IBD, depression etc. In collaboration with researchers at the Norwegian Institute of Public Health, in this project we are trying to understand the associations between infant gut microbiome and some early childhood health outcomes. Novel statististical methods are being developed for drawing such associations. 2. Study of DNA methylation in newborns of mothers who smoked during their pregnancy: Maternal smoking during pregnancy is known to be associated with a variety health outcomes in babies. In collaboration with Dr. Stephanie London (EB), we are investigating the effect of maternal smoking during pregnancy on DNA methylation in cord blood obtained from newborns. In Joubert et al. (EHP, 2012) we identified 26 epi-genome wide statistically significant CpGs that mapped onto 10 genes. In addition to AHRR and CYP1A1, we identified several novel genes (e.g. GFI1, MYO1G and RUNX1) that were not previously known to be associated with tobacco smoke. We are now conducting further investigation of these 26 CpG sites to understand the effect of sustained in-utero exposure to smoking throughout pregnancy and epigenetic inheritance of smoking-related modifications.

在2012-2013财年，该项目与校内和校外研究人员就广泛的主题进行了多次合作。这些合作产生了一些手稿，目前正处于不同的出版阶段。以下是一些合作的例子。