NIEHS Statistical Consulting Service

参与统计咨询服务的生物统计学家与联合国内外的科学家合作，共同撰写了几份研究出版物。下文列出了今年发表的宣言，还有一些宣言正在编写或处于审查进程的不同阶段。 我们合作研究的一些例子如下： 与休伊特等人（2010）合作，我们建立了一种没有雌激素受体α活性的基因敲除小鼠。 通过检测暴露于雌激素后的基因表达，我们能够更好地了解独立于雌激素受体α的生长因子的作用。 Kim等人（2010）通过敲除小鼠的核受体TAK 1/TR 4，我们观察到大脑的结构和功能变化。 在Jefferson等人（2009）中，我们发现小鼠在生命的前五天暴露于染料木黄酮（婴儿大豆配方奶粉中发现的染料木黄酮的一种形式）会破坏女性生殖系统的发育和功能。 在Schindler等人（2009）中，我们发现蛋白激酶p38 delta在皮肤肿瘤的发展中起着重要作用。

The biostatisticians participating in the statistical consulting service co-authored several research publications in collaboration with scientists within DIR and outisde the DIR. Manuscripts that were published during this year are listed below and there are several more that are either in preparation or in various stages of the review process. Some examples of our collaborative research are as follows: In collaboration with Hewitt et al. (2010), we created a knockout mouse that has no estrogen receptor alpha activity. By examining gene expression in response to exposure to estrogen, we were able to better understand the role of growth factors independent from estrogen receptor alpha. By knocking out the nuclear receptor, TAK1/TR4, in mice, in Kim et al. (2010) we observed structural and functional changes in the brain. In Jefferson et al. (2009), we found that exposure of mice to genistin, a form of genistein found in infant soy formula, during the first five days of life disrupted development and functioning of the female reproductive system later in life. In Schindler et al. (2009) we showed that the protein kinase p38delta plays an important role in skin tumor development.