Fibroid Growth Study

我们收集了各种数据，从随着时间推移(多达4个时间点)的肿瘤(肌瘤)体积的MRI测量，到从选择手术的女性获得的肿瘤基因表达微阵列数据。 目前，我们正在分析和总结迄今为止在这项研究中获得的各种数据。 我们研究了肿瘤生长与患者特征(种族、年龄和肌瘤数量)和肿瘤特征(子宫大小和位置)的关系。总共有78名女性参与了这项研究，总共贡献了279个肿瘤用于生长分析。 所有279个肿瘤的体积至少在两个时间点被测量；其中104个在所有四个时间点都被测量。 我们对这一数据的初步分析表明，无论是在女性之间还是在女性内部，肿瘤的平均生长都存在显著的差异。有趣的是，女性内部的差异是女性之间的两倍。在调整了患者和肿瘤特征后，我们的初步分析表明，不同种族、不同地点或不同肿瘤类型的增长率没有显著差异，但随着参与者的年龄和肿瘤数量的增加而下降。子宫内没有其他肌瘤的子宫肌瘤的生长速度明显大于子宫内有其他肌瘤的子宫肌瘤。

We have collected a variety of data, ranging from MRI measurements of tumor (fibroid) volumes over time (up to 4 time points) to gene expression microarray data obtained on tumors from women who opted for surgery. Currently we are in the process of analyzing and summarizing various data obtained in this study so far. We examined tumor growth in relation to patient characteristics (ethnicity, age, and number of fibroids) and tumor characteristics (size and position in the uterus). In all there were 78 women in the study contributing a total of 279 tumors for the analysis of growth. Volumes of all 279 tumors were measured at least at two time points; of these 104 were measured at all four time points. Our preliminary analysis of this data suggests that there was a significant variability in average tumor growth both, both between and within women. Interestingly, within woman variation was twice that of between women. After adjusting for patient and tumor characteristics, our preliminary analysis suggests that the growth rate does not differ significantly among races or locations or tumor types, but it decreases with age of the participant and with number of tumors. A fibroid with no other fibroids in the uterus has a significantly larger growth rate than if it had other fibroids in the uterus.