Fibroid Growth Study

肌瘤生长研究

• 批准号: 7594003
• 负责人: SHYAMAL PEDDADA
• 金额: $ 22万
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7594003
• 关键词: 18 year old; Age; Biological Markers; Blood specimen; Caliber; Characteristics; Clinical; Data; Data Analyses; Diagnosis; Enrollment; Ethnic Origin; Fibroid Tumor; Gene Expression; Growth; Health; Hysterectomy; Informed Consent; Leiomyoma; Life Style; Location; Magnetic Resonance Imaging; Measurement; Measures; Molecular; Numbers; Operative Surgical Procedures; Outcome; Participant; Patients; Phenotype; Population; Positioning Attribute; Pregnancy; Premenopause; Process; Questionnaires; Race; Range; Rate; Sampling; Symptoms; Telephone; Testing; Time; Ultrasonography; Update; Urine; Uterine Fibroids; Uterine myomectomy; Uterus; Variant; Visit; Week; Weight; Woman; clinically relevant; inclusion criteria; interest; reproductive; size; tumor; tumor growth

We have collected a variety of data, ranging from MRI measurements of tumor (fibroid) volumes over time (up to 4 time points) to gene expression microarray data obtained on tumors from women who opted for surgery. Currently we are in the process of analyzing and summarizing various data obtained in this study so far. We examined tumor growth in relation to patient characteristics (ethnicity, age, and number of fibroids) and tumor characteristics (size and position in the uterus). In all there were 78 women in the study contributing a total of 279 tumors for the analysis of growth. Volumes of all 279 tumors were measured at least at two time points; of these 104 were measured at all four time points. Our preliminary analysis of this data suggests that there was a significant variability in average tumor growth both, both between and within women. Interestingly, within woman variation was twice that of between women. After adjusting for patient and tumor characteristics, our preliminary analysis suggests that the growth rate does not differ significantly among races or locations or tumor types, but it decreases with age of the participant and with number of tumors. A fibroid with no other fibroids in the uterus has a significantly larger growth rate than if it had other fibroids in the uterus.

我们收集了各种数据，从肿瘤（纤维瘤）体积随时间变化的MRI测量（最多4个时间点）到选择手术的女性肿瘤的基因表达微阵列数据。 目前，我们正在分析和总结迄今为止在这项研究中获得的各种数据。 我们检查了肿瘤生长与患者特征（种族，年龄和肌瘤数量）和肿瘤特征（大小和在子宫中的位置）的关系。研究中共有78名女性参与了279个肿瘤的生长分析。 在所有279个肿瘤中，至少在两个时间点测量了20%;其中104个在所有四个时间点测量。 我们对这些数据的初步分析表明，女性之间和女性内部的平均肿瘤生长存在显著差异。 有趣的是，女性内部的差异是女性之间的两倍。在调整患者和肿瘤特征后，我们的初步分析表明，生长率在种族、地点或肿瘤类型之间没有显著差异，但随着参与者的年龄和肿瘤数量的增加而降低。 子宫内没有其他肌瘤的肌瘤比子宫内有其他肌瘤的肌瘤具有显著更大的生长速率。