ANIMAL HEALTH & SAMPLE PROCUREMENT CORE

核心B的总体目标是确保PPG动物的最佳健康和护理，以实现所有项目的特定目标。核心B是本PPG的核心要素，因为它负责动物资源、标本采集、健康评估的执行以及数据收集的所有方面，以便输入DR和老化数据库。为了实现这些目标，核心B有七个具体目标： 1.提供日常护理，包括必要的兽医和医疗，以确保所有PPG动物的健康和福祉。在这方面，核心B明确规定了每只动物将接受的研究程序。 2.维持营养定义的治疗组。我们的饮食和粮食分配调整的指标都有明确的指示。 3.收集和分发样品到实验室的适当项目。 4.定期进行健康评估。 5.协调从数据收集到数据输入的过渡。 6.进行完整的大体和显微镜研究，以记录疾病和死亡原因，并采购和储存组织用于未来的研究。记录疾病状态和死亡原因对于PPG长期目标至关重要。这需要彻底的肉眼和显微镜评价。 7.促进与NIA热量限制小组的沟通，以探索数据共享的潜在领域，并讨论疾病和治疗问题。

The over-arching goal of Core B is to assure optimal health and care of PPG animals to allow the Specific Aims of all projects to be achieved. Core B is a central element of this PPG as it is responsible for all aspects of the animal resource, specimen acquisition, performance of health assessments as well as collection of data for entry into the DR and aging database. To meet these goals, Core B has seven Specific Aims: 1. Provide daily care including veterinary and medical treatment as needed to assure health and well-being of all PPG animals. In this regard, Core B clearly defines study procedures that each animal will undergo. 2. Maintain nutritionally defined treatment groups. Our diets and indications for food allotment adjustments are clearly indicated. 3. Collect and dispense samples to the appropriate project of laboratory. 4. Conduct regular health assessments. 5. Coordinate transition from data collection to data entry. 6. Perform complete gross and microscopic study postmortem to document disease and cause of death, and procure and store tissues for future studies. Documentation of disease status and cause of death will be crucial to PPG long term goals. This requires thorough gross and microscopic evaluation. 7. Foster communication with the NIA calorie restriction group to explore potential areas of data sharing, and discuss disease and treatment issues.