RHESUS MACAQUE PSYCHOTROPIC DOSAGE ADMINISTRATION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Postmortem studies of human brains from patients with schizophrenia have implicated changes in gene expression in the inhibitory GABA(gamma amino butyric acid) and excitatory glutamate neurotransmitter systems. The importance of these findings is limited because of the possible confounds of treatment and medications. Therefore, it is important to determine the effects of these medications on gene expression in well-controlled experiments in primates. The aim of the experiments, now completed, was to determine the effects of commonly used psychotropic medications for the treatment of affective disorder schizophrenia and schizoaffective disorder on mRNA and protein expression in the brain.