RHESUS MACAQUE PSYCHOTROPIC DOSAGE ADMINISTRATION

恒河猴精神药物剂量管理

• 批准号: 7349655
• 负责人: Edward G Jones
• 金额: $ 4.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349655
• 关键词: RHESUS; MACAQUE; PSYCHOTROPIC; DOSAGE; ADMINISTRATION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Postmortem studies of human brains from patients with schizophrenia have implicated changes in gene expression in the inhibitory GABA(gamma amino butyric acid) and excitatory glutamate neurotransmitter systems. The importance of these findings is limited because of the possible confounds of treatment and medications. Therefore, it is important to determine the effects of these medications on gene expression in well-controlled experiments in primates. The aim of the experiments, now completed, was to determine the effects of commonly used psychotropic medications for the treatment of affective disorder schizophrenia and schizoaffective disorder on mRNA and protein expression in the brain.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的：对精神分裂症患者大脑的死后研究表明，抑制性GABA（γ氨基丁酸）和兴奋性谷氨酸神经递质系统的基因表达发生了变化。这些发现的重要性是有限的，因为治疗和药物可能混淆。因此，在控制良好的灵长类动物实验中确定这些药物对基因表达的影响是很重要的。这些实验现已完成，目的是确定用于治疗情感障碍精神分裂症和分裂情感障碍的常用精神药物对大脑中mRNA和蛋白质表达的影响。