Investigation into the role of MicroRNAs in pathogenesis of Marek's disease

MicroRNA在马立克氏病发病机制中的作用研究

• 批准号: BB/D012996/1
• 负责人: Venugopal Nair
• 金额: $ 36.01万
• 依托单位: The Pirbright Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FD012996%2F1
• 关键词: Investigation; into; role; MicroRNAs; pathogenesis

Marek's disease is one of the most contagious and widespread diseases affecting poultry health and welfare. The causative virus, called Marek's disease virus (MDV) induces a very severe form of cancer of the white blood cells (lymphocytes). Once infected, the virus can persist for the lifetime of the host and is continuously shed from the feather of the infected birds into the environment where it survives for long periods. The mechanisms by which MDV causes cancer is not known. The present project is aimed to identify the mechanisms of causation of the disease by the virus. Recently, several small RNA molecules called microRNAs (miRNAs) have been shown to be involved in different cellular processes including several human cancers. Such small miRNA molecules have been found in the chickens and we have also recently identified several miRNAs in the virus. The present project is aimed to examine whether these small miRNA are involved in the causation of MD.

马立克氏病是影响家禽健康和福利的最具传染性和广泛性的疾病之一。这种被称为马立克氏病病毒(MDV)的致病病毒会导致一种非常严重的白细胞(淋巴细胞)癌症。一旦感染，病毒可以在宿主的一生中持续存在，并不断从受感染鸟类的羽毛中释放到环境中，在那里它可以长期存活。MDV致癌的机制尚不清楚。本项目旨在确定该病毒引起疾病的机制。最近，几种被称为microRNAs(MiRNAs)的小RNA分子被证明参与了不同的细胞过程，包括几种人类癌症。在鸡中已经发现了这样的小miRNA分子，我们最近还在病毒中发现了几个miRNA。本项目的目的是研究这些小miRNA是否参与了MD的病因。

项目成果

Inhibition of v-rel-Induced Oncogenesis through microRNA Targeting.

• DOI: 10.3390/v10050242
• 发表时间: 2018-05-05
• 期刊: Viruses
• 作者: Yao Y;Zhang Y;Tang N;Pedrera M;Shen Z;Nair V
• 通讯作者: Nair V

Identification of an Intercistronic Internal Ribosome Entry Site in a Marek's Disease Virus Immediate-Early Gene

马立克氏病病毒立即早期基因顺反子间内部核糖体进入位点的鉴定

• DOI: 10.1128/jvi.02602-08
• 发表时间: 2009
• 期刊: Journal of Virology
• 影响因子: 5.4
• 作者: Tahiri-Alaoui A

Reticuloendotheliosis virus and avian leukosis virus subgroup J synergistically increase the accumulation of exosomal miRNAs.

网状内皮增生病毒和禽白血病病毒J亚型协同增加外泌体miRNA的积累

• DOI: 10.1186/s12977-018-0427-0
• 发表时间: 2018-07-03
• 期刊: Retrovirology
• 影响因子: 3.3
• 作者: Zhou D;Xue J;He S;Du X;Zhou J;Li C;Huang L;Nair V;Yao Y;Cheng Z
• 通讯作者: Cheng Z

The 5' leader of the mRNA encoding the marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties.

编码马立克氏病病毒血清型 1 pp14 蛋白的 mRNA 5 前导序列包含具有变构特性的内含子内部核糖体进入位点。

• DOI: 10.1128/jvi.01010-09
• 发表时间: 2009
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Tahiri-Alaoui A