APPLICATION OF MR IMAGING TO THE STUDY OF BONE DOSIMETRY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。博尔奇博士和他的同事使用磁共振显微镜对骨骼样本进行高分辨率成像，然后对图像进行分析，以测量骨骼结构和骨小梁密度。这些数据随后被用于辅助估计放射治疗的骨剂量学。大多数数据是使用4.7T仪器上的资源构造线圈收集的，但11T和750 MHz仪器仍在进行探索性研究。4.7T可以容纳相对较大的样品，并将这些样品中的小气泡引起的磁化率失真降至最低。敏感性效应是否能在更高领域的这些研究中被接受，还有待观察。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr Bolch and his co-workers use MR microscopy to image bone samples at high resolution, and then analyze the images to get measures of bone structure and trabecular density. These data are then used to aid in estimation of bone dosimetry for radiotherapy. Most data have been collected using Resource constructed coils on the 4.7T instrument, though exploratory studies on the 11T and 750MHz are being made. The 4.7T can accommodate relatively large samples and minimize susceptibility distortions that can arise from small bubbles in these samples. It remains to be seen if the susceptibility effects can be made acceptable for these studies at higher fields.