PREDICTORS OF HAART RESPONSIVENESS IN HIV DEMENTIA

HIV 痴呆中 HAART 反应的预测因素

• 批准号: 7379030
• 负责人: Joseph R Berger
• 金额: $ 1.48万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379030
• 关键词: PREDICTORS; HAART; RESPONSIVENESS; HIV; DEMENTIA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims of this proposal are 1) to determine the relationship of metabolic and microvascular indices measured by MR to neuropsychologic status and to biological markers of the different proposed mechanisms of CNS toxicity and 2) to correlate the clinical/neurologic response to HAART (therapy, composed of multiple anti-HIV drugs) with the metabolic and microvascular responses in the CNS.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项建议的具体目的是：1)确定MR测量的代谢和微血管指数与神经心理状态和提出的不同中枢神经系统毒性机制的生物学标志物的关系；2)确定HAART(由多种抗HIV药物组成的治疗)的临床/神经学反应与中枢神经系统代谢和微血管反应的关系。