SLEEP DISTURBANCE AND PAIN SENSITIVITY IN CHRONIC PAIN

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在5000万患有慢性疼痛的成年人中，有50-80%的人受到睡眠障碍的影响，这是与疼痛最相关的因素之一。流行病学研究支持睡眠障碍大大增加严重的医学和精神疾病的风险的论点，但慢性疼痛的睡眠研究是有限的。对健康受试者的研究表明，睡眠和疼痛是相互关联的，比如疼痛会扰乱睡眠，而睡眠中断又会加剧疼痛。这种关系在临床人群中研究不足，缺乏治疗的经验方法。这些研究者提出了一项与颞下颌关节紊乱（TMD）相关的慢性肌筋膜疼痛患者的纵向研究。本研究的目的是：1)表征与TMD相关的睡眠障碍；2)确定失眠和/或睡眠微结构异常的诊断是否与机械性咀嚼肌疼痛增加有关；3)评估基线睡眠连续性和/或NREM睡眠微结构特征是否能预测TMD疼痛的后续病程。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sleep disturbance is one of the most disabling correlates of pain affecting between 50-80% of the 50 million adults suffering from chronic pain. Epidemiologic research supports the contention that sleep disturbance substantially increases risk for serious medical and psychiatric morbidities, but sleep research in chronic pain is limited. Research in healthy subjects suggests that sleep and pain are reciprocally linked, such that pain disrupts sleep and sleep disruption exacerbates pain. This relationship has been inadequately studied in clinical populations and empirical approaches to treatment are lacking. These investigators propose a longitudinal study of patients with chronic myofascial pain associated with temporomandibular joint disorder (TMD). The aims of this study are to 1) characterize sleep disturbances associated with TMD 2) determine whether the diagnosis of insomnia and or sleep microstructure abnormalities are associated with increased mechanical masticatory muscle pain, and 3) to evaluate whether baseline sleep continuity and/or NREM sleep microstructure profiles predict the subsequent course of TMD pain.