PREVALENCE OF METABOLIC DISTURBANCES IN PATIENTS USING ANTIPSYCHOTIC MEDICATION:

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。新的抗精神病药物被称为非典型抗精神病药物，有助于减轻精神病症状，并已被广泛用于精神分裂症和其他精神障碍患者。然而，过去几年积累的证据表明，与非典型抗精神病药物相关的代谢紊乱（如糖尿病和高胆固醇或高脂肪含量）可能很常见。由于精神病患者也往往是心血管疾病风险因素增加的患者，如吸烟和久坐不动的生活方式，这项初步研究希望确定服用抗精神病药物的个体，他们有这些代谢异常，并试图了解为什么以及如何他们可能更危险。研究的参与者将接受临床病史审查，对血压，体重，身高，腰围和臀围进行身体测量，并在参与者处于空腹状态时进行一系列三次抽血（即，在测试前一天午夜后不进食）以确定身体的葡萄糖水平，胰岛素和脂肪，以及一个特定的测试称为葡萄糖耐量测试，以确定他们的身体的能力，利用葡萄糖。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The newer antipsychotic medications known as the atypical antipsychotic medications have helped to alleviate symptoms of psychosis and have become widely used in patients with schizophrenia and other psychotic disorders. However, accumulating evidence over the past years suggests that metabolic disturbances (conditions such as diabetes and high cholesterol or high fat content) associated with the atypical antipsychotics may be common. Since patients with psychosis also tend to be the ones with increased risk factors for cardiovascular disease such as smoking and sedentary lifestyle, this pilot study hopes to identify individuals on antiphysotic medications who have these metabolic abnormalities and try to understand why and how they may be more at risk. Participants in the study will undergo clinical history review, a physical measurement of blood pressure, weight, height, waist and hip circumference, and a series of three blood draws will be done while participants are in a fasting state (that is, not food intake after midnight the night prior to testing) to determine the body's level of glucose, insulin and fat as well as a specific test known as the glucose tolerance test to determine their body's ability to use glucose.